Chemosensory anhedonia facilitates depressive symptoms and cognitive impairment in late-life depression

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-12 DOI:10.1111/ggi.14968

Jiafu Li, Ben Chen, Qiang Wang, Danyan Xu, Hanna Lu, Gaohong Lin, Mingfeng Yang, Jingyi Lao, Yijie Zeng, Shuang Liang, Kexin Yao, Qin Liu, Yuanling Huang, Xiaoxi Liu, Xiaomei Zhong, Yuping Ning

{"title":"Chemosensory anhedonia facilitates depressive symptoms and cognitive impairment in late-life depression","authors":"Jiafu Li, Ben Chen, Qiang Wang, Danyan Xu, Hanna Lu, Gaohong Lin, Mingfeng Yang, Jingyi Lao, Yijie Zeng, Shuang Liang, Kexin Yao, Qin Liu, Yuanling Huang, Xiaoxi Liu, Xiaomei Zhong, Yuping Ning","doi":"10.1111/ggi.14968","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>Chemosensory anhedonia refers to the lack of hedonic ability to experience pleasure through the senses of smell and taste, which reduces the pleasure and comfort of food, and increases the risk of nutritional and immune deficiencies. However, there is no direct scientific evidence regarding chemosensory anhedonia in patients with late-life depression (LLD). The aim of this study was to investigate chemosensory anhedonia in patients with LLD, and its potential association with depressive symptoms and cognitive function.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 114 patients with LLD and 92 normal controls were included in this study. They experienced clinical assessment, Chemosensory Pleasure Scale assessment, 17-item Hamilton Depression Rating Scale assessment and cognitive assessments, which contain the Verbal Fluency Test. The associations between chemosensory pleasure and depressive symptoms or cognitive function in patients with LLD were explored using partial correlation analysis and mediation analysis.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The Chemosensory Pleasure Scale scores were lower in the LLD group than in the normal control group, and were negatively correlated with the total scores and factors' scores (retardation, cognitive bias and anxiety/somatization) of the 17-item Hamilton Depression Rating Scale, and positively correlated with the Verbal Fluency Test scores. The scores for the Food and Imagination dimensions of the Chemosensory Pleasure Scale showed partial mediating effects on the differences in Cognitive bias (a factor of the 17-item Hamilton Depression Rating Scale) between patients with LLD and normal controls.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Patients with LLD showed significant chemosensory anhedonia, and both depressive symptoms and cognitive impairment were associated with the severity of chemosensory anhedonia. Enhancing chemosensory pleasure in patients with LLD could potentially ameliorate their depressive symptoms. <b>Geriatr Gerontol Int 2024; 24: 1022–1029</b>.</p>\n </section>\n </div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ggi.14968","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

Chemosensory anhedonia refers to the lack of hedonic ability to experience pleasure through the senses of smell and taste, which reduces the pleasure and comfort of food, and increases the risk of nutritional and immune deficiencies. However, there is no direct scientific evidence regarding chemosensory anhedonia in patients with late-life depression (LLD). The aim of this study was to investigate chemosensory anhedonia in patients with LLD, and its potential association with depressive symptoms and cognitive function.

Methods

A total of 114 patients with LLD and 92 normal controls were included in this study. They experienced clinical assessment, Chemosensory Pleasure Scale assessment, 17-item Hamilton Depression Rating Scale assessment and cognitive assessments, which contain the Verbal Fluency Test. The associations between chemosensory pleasure and depressive symptoms or cognitive function in patients with LLD were explored using partial correlation analysis and mediation analysis.

Results

The Chemosensory Pleasure Scale scores were lower in the LLD group than in the normal control group, and were negatively correlated with the total scores and factors' scores (retardation, cognitive bias and anxiety/somatization) of the 17-item Hamilton Depression Rating Scale, and positively correlated with the Verbal Fluency Test scores. The scores for the Food and Imagination dimensions of the Chemosensory Pleasure Scale showed partial mediating effects on the differences in Cognitive bias (a factor of the 17-item Hamilton Depression Rating Scale) between patients with LLD and normal controls.

Conclusions

Patients with LLD showed significant chemosensory anhedonia, and both depressive symptoms and cognitive impairment were associated with the severity of chemosensory anhedonia. Enhancing chemosensory pleasure in patients with LLD could potentially ameliorate their depressive symptoms. Geriatr Gerontol Int 2024; 24: 1022–1029.

查看原文本刊更多论文

化学感觉失调会加重晚年抑郁症的抑郁症状和认知障碍

目的化感失调是指缺乏通过嗅觉和味觉体验快乐的享乐能力，从而降低了食物带来的愉悦感和舒适感，并增加了营养和免疫缺陷的风险。然而，关于晚年抑郁症（LLD）患者的化学感觉失调，目前还没有直接的科学证据。本研究旨在调查晚期抑郁症患者的化学感觉失调及其与抑郁症状和认知功能的潜在联系。他们接受了临床评估、化学感觉快感量表评估、17项汉密尔顿抑郁量表评估和认知评估（包括言语流畅性测试）。结果 LLD组的化感快感量表得分低于正常对照组，与17项汉密尔顿抑郁评定量表的总分和因子分（迟钝、认知偏差和焦虑/焦躁）呈负相关，与言语流畅性测试得分呈正相关。LLD患者与正常对照组之间在认知偏差（17项汉密尔顿抑郁分级量表的一个因子）方面的差异，在化感快感量表的食物和想象维度上的得分显示出部分中介效应。增强 LLD 患者的化感快感可能会改善他们的抑郁症状。Geriatr Gerontol Int 2024; --：-----.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464