Effect and interaction of PINK1 genetic polymorphisms and environmental factors on blood pressure in COEs-exposed workers.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-09-18 DOI:10.1080/09603123.2024.2403685

Jing Sun,Yang Chen,Xiangkai Zhao,Zeming Niu,Zhiguang Gu,Zhaofan Yan,Wei Wang

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引用次数: 0

Abstract

Coke oven emissions (COEs) contain a variety of polycyclic aromatic hydrocarbons (PAHs), which can cause damage to the human cardiovascular system. In addition, myocardial mitochondria are susceptible to damage in hypertensive patients. However, it is not clear whether genetic variation, in single nucleotide polymorphisms (SNPs) in PINK1 affects COEs exposure-induced abnormal blood pressure. We surveyed and tested 518 workers exposed to COEs and statistically analyzed them with SPSS 21.0 software. SBP was greater in the high-exposure group than in the low-exposure group. Generalized linear model analysis showed that the interaction of PINK1 rs3738136 (GA+AA) and COEs had an effect on SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] and DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]. This study is the first to identify the role of PINK1 rs3738136 in COE- induced abnormal blood pressure, and to prove that the abnormal blood pressure of workers is the result of environmental and genetic factors.

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PINK1 基因多态性和环境因素对接触 COE 的工人血压的影响和相互作用。

焦炉排放物（COEs）含有多种多环芳烃（PAHs），可对人体心血管系统造成损害。此外，高血压患者的心肌线粒体也容易受损。然而，PINK1 的单核苷酸多态性（SNPs）遗传变异是否会影响 COEs 暴露引起的血压异常，目前尚不清楚。我们对 518 名接触 COEs 的工人进行了调查和测试，并使用 SPSS 21.0 软件进行了统计分析。高接触组的 SBP 高于低接触组。广义线性模型分析表明，PINK1 rs3738136 (GA+AA) 与 COEs 的交互作用对 SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] 和 DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]有影响。本研究首次确定了 PINK1 rs3738136 在 COE 诱导的血压异常中的作用，并证明工人的血压异常是环境和遗传因素共同作用的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.