Synthesis of (bi)pyridine derivatives of ornidazole

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-09-19 DOI:10.1007/s11172-024-4352-1

E. A. Kudryashova, M. I. Valieva, N. V. Slovesnova, A. V. Bolotova, Yu. M. Sayfutdinova, S. E. Vatolina, I. L. Nikonov, K. V. Grzhegorzhevskii, D. S. Kopchuk, G. V. Zyryanov, V. L. Rusinov

引用次数: 0

Abstract

New (bi)pyridine derivatives of the antimicrobial drug ornidazole were synthesized by alkylation of pyridyl- and 2,2′-bipyridyl-phenolic derivatives for the first time. The proposed methodology makes it possible to expand the range of ornidazole derivatives with increased antibacterial activity.

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奥硝唑（双）吡啶衍生物的合成

通过对吡啶基和 2,2′-联吡啶基酚衍生物进行烷基化，首次合成了抗菌药物奥硝唑的新（双）吡啶衍生物。所提出的方法使得扩大具有更强抗菌活性的奥硝唑衍生物的范围成为可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.