Nathaly de Oliveira Ciaramicolo DDS, MS , Gabriela Barbosa Bisson DDS, MS , Osny Ferreira Júnior DDS, MSc
{"title":"Adverse effects associated with the irresponsible use of phenol peeling: literature review","authors":"Nathaly de Oliveira Ciaramicolo DDS, MS , Gabriela Barbosa Bisson DDS, MS , Osny Ferreira Júnior DDS, MSc","doi":"10.1016/j.oooo.2024.08.018","DOIUrl":null,"url":null,"abstract":"<div><div>Carbolic acid or phenol is considered a chemical agent that produces intense facial rejuvenation when used correctly, however, solutions containing this substance are dangerous and their action must be controlled. The aim of this study was to collect information on the adverse effects of the use of phenolic compounds for facial esthetic purposes. Phenol promotes the denaturation and coagulation of epidermal keratin proteins, deep chemical peels carried out with phenol, when well indicated and properly conducted, produce incomparable results, however, the ignorant use of these solutions can produce ectropion, keloids, and unsightly scars on the face and neck, in addition, systemic absorption is related to hepatorenal and cardiac toxicity. Although the cardiotoxicity of phenol is well described in the literature, its carcinogenic potential is still unknown and further studies are needed. It is known that the substance induces unscheduled DNA synthesis, inducing genetic mutation. Successful results depend on a balance among art and technique and safety standards. Future research investigating the carcinogenic potential of phenol peels is desirable to ensure patient safety and adequate information for professionals. We believe that the indiscriminate use of phenol peels can cause serious problems for patients and their general health. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Pages 161-165"},"PeriodicalIF":2.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440324004498","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Carbolic acid or phenol is considered a chemical agent that produces intense facial rejuvenation when used correctly, however, solutions containing this substance are dangerous and their action must be controlled. The aim of this study was to collect information on the adverse effects of the use of phenolic compounds for facial esthetic purposes. Phenol promotes the denaturation and coagulation of epidermal keratin proteins, deep chemical peels carried out with phenol, when well indicated and properly conducted, produce incomparable results, however, the ignorant use of these solutions can produce ectropion, keloids, and unsightly scars on the face and neck, in addition, systemic absorption is related to hepatorenal and cardiac toxicity. Although the cardiotoxicity of phenol is well described in the literature, its carcinogenic potential is still unknown and further studies are needed. It is known that the substance induces unscheduled DNA synthesis, inducing genetic mutation. Successful results depend on a balance among art and technique and safety standards. Future research investigating the carcinogenic potential of phenol peels is desirable to ensure patient safety and adequate information for professionals. We believe that the indiscriminate use of phenol peels can cause serious problems for patients and their general health. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
期刊介绍:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.