Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Pub Date : 2024-09-03 DOI:10.1016/j.oooo.2024.08.020

Tadayoshi Nobumoto DDS PhD, Sachiko Yamasaki DDS PhD, Atsuko Hamada DDS PhD, Mirai Higaki DDS PhD, Nanako Ito DDS PhD, Fumitaka Obayashi DDS PhD, Yasutaka Ishida DDS PhD, Tomoaki Hamana DDS PhD, Tomoaki Shintani DDS PhD, Ryouji Tani DDS PhD, Koichi Koizumi DDS PhD, Souichi Yanamoto DDS PhD, Yasutaka Hayashido DDS PhD

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Abstract

Claudin (CLD), a major component of tight junctions, is a four-transmembrane protein, and 24 subtypes have been reported in humans. CLD expression is highly tissue-specific; CLD1 has been reported to be expressed in the skin and mucosa. There have been few reports on CLD1 expression and its function in oral cancer.

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克劳丁-1 在口腔鳞状细胞癌细胞中的临床意义和生物学作用

Claudin（CLD）是紧密连接的主要成分，是一种四跨膜蛋白，据报道在人类中有 24 种亚型。CLD 的表达具有高度的组织特异性；据报道，CLD1 在皮肤和粘膜中均有表达。有关 CLD1 在口腔癌中的表达及其功能的报道很少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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