Physical activity and frontoparietal network connectivity in traumatic brain injury

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Emma M. Tinney, Meishan Ai, Goretti España-Irla, Charles H. Hillman, Timothy P. Morris
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引用次数: 0

Abstract

Background

Prolonged changes to functional network connectivity as a result of a traumatic brain injury (TBI) may relate to long-term cognitive complaints reported by TBI survivors. No interventions have proven to be effective at treating long-term cognitive complaints after TBI but physical activity has been shown to promote cognitive function and modulate functional network connectivity in non-injured adults. Therefore, the objective of this study was to test if physical activity engagement was associated with functional connectivity of the cognitively relevant frontoparietal control network (FPCN) in adults with a TBI history.

Methods

In a case-control study design, resting state function magnetic resonance imaging and physical activity data from a subset of participants (18–81 years old) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study was analyzed. Fifty-seven participants reported a prior head injury with loss of consciousness and 57 age and sex matched controls were selected. Seed-based functional connectivity analyses were performed using seeds in the dorsolateral prefrontal cortex and the inferior parietal lobule, to test for differences in functional connectivity between groups, associations between physical activity and functional connectivity within TBI as well as differential associations between physical activity and functional connectivity between TBI and controls.

Results

Seed-based connectivity analyses from the dorsolateral prefrontal cortex showed that those with a history of TBI had decreased positive connectivity between dorsolateral prefrontal cortex and intracalcarine cortex, lingual gyrus, and cerebellum, and increased positive connectivity between dorsolateral prefrontal cortex and cingulate gyrus and frontal pole in the TBI group. Results showed that higher physical activity was positively associated with increased connectivity between the dorsolateral prefrontal cortex and inferior temporal gyrus. Differential associations were observed between groups whereby the strength of the physical activity-functional connectivity association was different between the inferior parietal lobule and inferior temporal gyrus in TBI compared to controls.

Discussion

Individuals with a history of TBI show functional connectivity alterations of the FPCN. Moreover, engagement in physical activity is associated with functional network connectivity of the FPCN in those with a TBI. These findings are consistent with the evidence that physical activity affects FPCN connectivity in non-injured adults; however, this effect presents differently in those with a history of TBI.

Abstract Image

Abstract Image

体育锻炼与创伤性脑损伤的额顶叶网络连接
创伤性脑损伤(TBI)导致的功能性网络连接的长期变化可能与创伤性脑损伤幸存者报告的长期认知问题有关。目前还没有任何干预措施被证明能有效治疗创伤性脑损伤后的长期认知症状,但体育活动已被证明能促进认知功能并调节未受伤成年人的功能网络连接。因此,本研究的目的是测试体育锻炼是否与有创伤性脑损伤病史的成年人认知相关的额顶叶控制网络(FPCN)的功能连接有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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