Mechanisms Underlying Ophiocordyceps Infection and Behavioral Manipulation of Ants: Unique or Ubiquitous?

IF 8.5 1区 生物学 Q1 MICROBIOLOGY
Emmeline van Roosmalen, Charissa de Bekker
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引用次数: 0

Abstract

Parasite manipulation of host behavior, as an effective strategy to establish transmission, has evolved multiple times across taxa, including fungi. Major strides have been made to propose molecular mechanisms that underlie manipulative parasite-host interactions including the manipulation of carpenter ant behavior by Ophiocordyceps. This research suggests that the secretion of parasite proteins and light-driven biological rhythms are likely involved in the infection and manipulation biology of Ophiocordyceps and other manipulating parasites. Here, we discuss research on Ophiocordyceps considering findings from other (fungal) parasites that either are relatively closely related (e.g., other insect- and plant-infecting Hypocreales) or also manipulate insect behavior (e.g., Entomophthorales). As such, this review aims to put forward this question: Are the mechanisms behind Ophiocordyceps manipulation and infection unique, or did they convergently evolve? From this discussion, we pose functional hypotheses about the infection biology of Ophiocordyceps that will need to be addressed in future studies.
虫草蛇毒素感染和蚂蚁行为操纵的机制:独特还是普遍?
寄生虫操纵宿主行为作为一种建立传播的有效策略,已经在包括真菌在内的不同类群中进化了多次。在提出操纵寄生虫-宿主相互作用的分子机制方面取得了重大进展,其中包括虫草蛇对木匠蚁行为的操纵。这些研究表明,寄生虫蛋白质的分泌和光驱动的生物节律很可能参与了蛇尾蝇蛆和其他操纵性寄生虫的感染和操纵生物学。在此,我们讨论了关于蛇尾蝇蛆的研究,同时考虑了其他(真菌)寄生虫的研究结果,这些寄生虫要么与蛇尾蝇蛆有相对密切的关系(如其他昆虫和植物感染下孢子虫科),要么也操纵昆虫的行为(如昆虫口器虫科)。因此,本综述旨在提出这一问题:线虫操纵和感染背后的机制是独特的,还是趋同进化的?通过讨论,我们提出了关于蛇尾藻感染生物学的功能性假设,这些假设需要在未来的研究中加以解决。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of microbiology
Annual review of microbiology 生物-微生物学
CiteScore
18.10
自引率
0.00%
发文量
37
期刊介绍: Annual Review of Microbiology is a Medical and Microbiology Journal and published by Annual Reviews Inc. The Annual Review of Microbiology, in publication since 1947, covers significant developments in the field of microbiology, encompassing bacteria, archaea, viruses, and unicellular eukaryotes. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license. The Impact Factor of Annual Review of Microbiology is 10.242 (2024) Impact factor. The Annual Review of Microbiology Journal is Indexed with Pubmed, Scopus, UGC (University Grants Commission).
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