The role of microRNAs in the regulation of critical genes and signalling pathways that determine endometrial receptivity

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-18 DOI:10.1017/s0967199424000297

Yumei Wang, Zhongxiang Ji, Ni Yao, Ximin Hu, Ran Zhou, Xingping Wang, Zhuoma Luoreng

引用次数: 0

Abstract

Summary Endometrial receptivity is the ability of the endometrium to accept embryos. Thus, endometrial receptivity dysfunction is an important factor leading to embryo implantation failure. A good endometrial receptivity provides a suitable environment for embryo implantation, improving the embryo implantation rate. The “implantation window” stage, or the receptive stage of the endometrium, is regulated by various hormones, genes, proteins and cytokines, among which microRNAs (miRNAs) and their target genes have a regulatory effect on endometrial receptivity. This review outlines the relationship between endometrial receptivity and pregnancy, the mRNAs and related signalling pathways that regulate endometrial receptivity, and the regulatory role of miRNA in endometrial receptivity, providing a deeper understanding of the regulatory mechanisms of miRNA on endometrial receptivity in humans and animals and reference for the endometrial receptivity-related research.

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微小核糖核酸在调控决定子宫内膜接受能力的关键基因和信号通路中的作用

摘要子宫内膜接受能力是指子宫内膜接受胚胎的能力。因此，子宫内膜接受功能障碍是导致胚胎植入失败的一个重要因素。良好的子宫内膜接受能力可为胚胎植入提供适宜的环境，提高胚胎植入率。植入窗 "阶段或子宫内膜的接受阶段受多种激素、基因、蛋白质和细胞因子的调控，其中微 RNA（miRNA）及其靶基因对子宫内膜的接受能力具有调控作用。本综述概述了子宫内膜容受性与妊娠的关系、调控子宫内膜容受性的mRNA及相关信号通路，以及miRNA在子宫内膜容受性中的调控作用，为深入了解miRNA对人类和动物子宫内膜容受性的调控机制，以及子宫内膜容受性相关研究提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.