The rare case of synchronous bilateral breast metastasis from a lung neuroendocrine tumor (small cell lung carcinoma): a case report and literature review

IF 0.7 Q4 SURGERY
Ayaka Shimo, Koichiro Tsugawa, Kaori Sakamaki, Mina Kitajima, Mariko Takishita, Mizuho Tazo, Mari Nakano, Takako Kuroda, Ai Motoyoshi, Makiko Tsuzuki, Toru Nishikawa, Hisanori Kawamoto, Masatomo Doi
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Abstract

Breast metastasis from small cell neuroendocrine carcinoma (SNEC) is very rare. In the present report, we describe a case of a female patient who was initially diagnosed with triple negative primary bilateral breast cancer, but during systemic examination, the diagnosis was bilateral breast metastasis from SNEC. A 62-year-old woman with no history of smoking presented to the Department of General Medicine with left-sided chest pain, and computed tomography revealed masses in both breasts and left pleural thickening that was further confirmed by mammography and ultrasound of the breasts. A needle biopsy was performed, and triple negative primary bilateral breast cancer was diagnosed. Because progastrin-releasing peptide (ProGRP) 37,300 pg/ml (normal range, 0–81.0 pg/ml) and neuron-specific enolase 35.0 ng/ml (normal range, 0–16.3 ng/ml) levels were elevated, thoracoscopic biopsy was performed, and SNEC was diagnosed. Pathological examinations showed that the bilateral breast masses were also positive for immunohistochemical staining of chromogranin A, synaptophysin, and CD56, leading to a diagnosis of bilateral breast metastasis of neuroendocrine tumor. Although very rare, the possibility of breast metastasis should be considered when malignancy is suspected in other organs.
肺神经内分泌瘤(小细胞肺癌)双侧乳腺同步转移的罕见病例:病例报告和文献综述
小细胞神经内分泌癌(SNEC)的乳房转移非常罕见。在本报告中,我们描述了一例女性患者的病例,她最初被诊断为三阴性原发性双侧乳腺癌,但在系统检查中被诊断为小细胞神经内分泌癌的双侧乳房转移。一名 62 岁的女性患者无吸烟史,因左侧胸痛到全科就诊,计算机断层扫描发现双侧乳房肿块和左侧胸膜增厚,乳房 X 线照相术和乳房超声波检查进一步证实了这一点。进行了针刺活检,确诊为三阴性原发性双侧乳腺癌。由于胃泌素释放肽(ProGRP)37,300 pg/ml(正常范围:0-81.0 pg/ml)和神经元特异性烯醇化酶(neuron-specific enolase)35.0 ng/ml(正常范围:0-16.3 ng/ml)水平升高,患者接受了胸腔镜活检,并被诊断为SNEC。病理检查显示,双侧乳房肿块的嗜铬粒蛋白 A、突触素和 CD56 免疫组化染色也呈阳性,因此诊断为神经内分泌肿瘤的双侧乳房转移。虽然非常罕见,但当怀疑其他器官有恶性肿瘤时,应考虑乳腺转移的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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审稿时长
13 weeks
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