Increased Expression of PDGFA Is Associated With Poor Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-18 DOI:10.1111/jop.13579

Kaiqin Wang, Changya Li, Huarong Chen, Ping Gu, Jiafeng Lu, Houyu Zhao, Xianlu Zhuo

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引用次数: 0

Abstract

Background

Platelet-derived growth factor A (PDGFA) has been shown to be upregulated in several tumors, contributing to their malignant phenotypes. However, its expression and function in head and neck squamous cell carcinoma (HNSC) are not clearly understood. Thus, we aimed to evaluate this issue using bioinformatic analyses and primary experimental validation.

Methods

The expression of PDGFA was analyzed using popular bio-databases and further validated by RT-PCR and immunohistochemical staining. Survival analyses were then performed. The association between PDGFA expression levels and immune cell infiltration in the immune microenvironment was assessed.

Results

PDGFA has been found to be significantly upregulated in a variety of cancers, including HNSC, and increased PDGFA expression may be an independent prognostic factor associated with immune cell infiltration in HNSC.

Conclusion

Overexpression of PDGFA in HNSC is significantly associated with poor prognosis and immune cell infiltration in the tumor microenvironment (TME). PDGFA has potential as a molecular indicator for diagnosis, prognosis, and immune processes in HNSC.

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头颈部鳞状细胞癌中 PDGFA 的表达增加与预后不良和免疫渗透有关。

背景血小板衍生生长因子 A（PDGFA）已被证明在多种肿瘤中上调，从而导致其恶性表型。然而，它在头颈部鳞状细胞癌（HNSC）中的表达和功能尚不清楚。方法利用流行的生物数据库分析 PDGFA 的表达，并通过 RT-PCR 和免疫组化染色进一步验证。然后进行了生存分析。结论PDGFA在HNSC中的过表达与不良预后和肿瘤微环境（TME）中的免疫细胞浸润显著相关。PDGFA 有可能成为 HNSC 诊断、预后和免疫过程的分子指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464