The value and accuracy of intracoronary electrocardiogram in the diagnosis of myocardial ischemia in coronary heart disease.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-29 DOI:10.3233/thc-240837

Shanwen Zhang,Zhimin Bao,Taotao Liao,Zhenying Pei,Shiyu Yang,Chunjiao Zhao,Yuping Zhang

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Abstract

BACKGROUND Although intracoronary electrocardiography (IC-ECG) offers direct electrophysiological insights into myocardial ischemia caused by insufficient coronary blood supply, compared to common diagnostic methods like electrocardiography (ECG), it lacks widespread adoption and robust clinical research. OBJECTIVE To analyze the value and accuracy of intracoronary electrocardiogram in myocardial ischemia diagnosis in coronary heart disease patients. METHODS Three hundred patients treated at our hospital were included in the study. Patients were categorized into non-ischemic group A (Fraction Flow Reserve [FFR] > 0.8) and ischemic group B (FFR < 0.75) based on FFR examination results. Both groups underwent IC-ECG examination. The ischemic group received percutaneous coronary intervention (PCI) treatment followed by another FFR examination, dividing them into non-ischemic subgroup B1 (FFR > 0.8) and ischemic subgroup B2 (FFR < 0.75). Both subgroups underwent IC-ECG examination. Receiver operating curves were constructed using FFR to assess the clinical utility of different IC-ECG parameters. RESULTS Group A patients showed a significant decrease in ST-segment shift at J-point, ST-segment integral, T-peak, T-wave integral, and T-peak to end-time, while the Corrected Q-T interval (QTc-time) was significantly higher in the B group (p< 0.05). The parameters, including ST-segment shift at J-point, ST-segment integral, T-wave integral, T-peak, T-peak to end-time, and QTc-time, were found to have clinical significance in predicting the occurrence of myocardial ischemia (p< 0.05). CONCLUSION Intracoronary electrocardiogram QT interval dispersion and Q-T peak (QTp) interval dispersion have a high diagnostic accuracy for myocardial ischemia in coronary heart disease.

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冠状动脉内心电图在诊断冠心病心肌缺血中的价值和准确性。

背景虽然与心电图（ECG）等常见诊断方法相比，冠状动脉内心电图（IC-ECG）可直接从电生理角度了解冠状动脉供血不足导致的心肌缺血，但它缺乏广泛的应用和有力的临床研究。根据 FFR 检查结果，将患者分为非缺血 A 组（FFR > 0.8）和缺血 B 组（FFR < 0.75）。两组均接受 IC-ECG 检查。缺血组接受经皮冠状动脉介入（PCI）治疗，然后再次进行 FFR 检查，将其分为非缺血亚组 B1（FFR > 0.8）和缺血亚组 B2（FFR < 0.75）。两个亚组均接受了 IC-ECG 检查。结果 A组患者的J点ST段移位、ST段积分、T峰、T波积分和T峰至终点时间显著下降，而B组患者的校正Q-T间期（QTc-time）显著升高（P< 0.05）。结论冠状动脉心电图 QT 间期弥散和 Q-T 峰（QTp）间期弥散对冠心病心肌缺血有较高的诊断准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.