Smoking Cessation and Incident Atrial Fibrillation in a Longitudinal Cohort

IF 8 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Justin T. Teraoka MD, MAS , Janet J. Tang PhD, MPH , Francesca N. Delling MD, MPH , Eric Vittinghoff PhD , Gregory M. Marcus MD, MAS
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引用次数: 0

Abstract

Background

Although smoking heightens the risk of AF, it remains unknown if that risk is amenable to modification after smoking cessation.

Objectives

This study sought to evaluate the association between smoking cessation and atrial fibrillation (AF) risk in a large longitudinal cohort.

Methods

After excluding those with prevalent AF and no history of smoking at baseline, we evaluated 146,772 UK Biobank participants with serial smoking assessments. We compared AF risk between former smokers at baseline and those who quit smoking during the study to current smokers. Incident AF was ascertained from outpatient and inpatient encounters and identified using International Classification of Diseases codes. Cox models were used to compare the risk of incident AF among current and former smokers as well as those who quit smoking during the study while controlling for age, sex, race, body mass index, education, cardiovascular comorbidities, alcohol use, and pack-years.

Results

Among the 146,772 participants (48.3% female; age: 57.3 ± 7.9 years), 37,377 (25.5%) currently smoked; 105,429 (72.0%) were former smokers; and 3,966 (2.7%) quit smoking during the study. Over a mean 12.7 ± 2.0 years of follow-up, 11,214 (7.6%) participants developed AF. Compared to current smokers, the adjusted risk of AF was 13% lower in former smokers (HR: 0.87; 95% CI: 0.83-0.91) and 18% lower in those who quit smoking during the study (HR: 0.82; 95% CI: 0.70-0.95).

Conclusions

Compared to those who continue to smoke, smoking cessation was associated with a lower risk of AF.
纵向队列中的戒烟与心房颤动发病率
背景虽然吸烟会增加心房颤动的风险,但戒烟后这一风险是否会发生改变仍是未知数。目的本研究试图在一个大型纵向队列中评估戒烟与心房颤动(AF)风险之间的关系。方法在排除了那些心房颤动流行且基线时无吸烟史的人群后,我们对 146,772 名英国生物库参与者进行了连续吸烟评估。我们比较了基线时曾经吸烟者和研究期间戒烟者与当前吸烟者的房颤风险。心房颤动事件通过门诊和住院病例确定,并使用国际疾病分类代码进行识别。在控制年龄、性别、种族、体重指数、教育程度、心血管并发症、饮酒和吸烟包年的情况下,使用 Cox 模型比较现吸烟者、曾吸烟者和研究期间戒烟者发生房颤的风险。结果在 146,772 名参与者(48.3% 为女性;年龄:57.3 ± 7.9 岁)中,37,377 人(25.5%)目前吸烟;105,429 人(72.0%)曾经吸烟;3,966 人(2.7%)在研究期间戒烟。在平均 12.7 ± 2.0 年的随访期间,11214 名参与者(7.6%)患上了房颤。与当前吸烟者相比,曾经吸烟者发生房颤的调整后风险降低了 13%(HR:0.87;95% CI:0.83-0.91),而在研究期间戒烟者发生房颤的风险降低了 18%(HR:0.82;95% CI:0.70-0.95)。
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来源期刊
JACC. Clinical electrophysiology
JACC. Clinical electrophysiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
10.30
自引率
5.70%
发文量
250
期刊介绍: JACC: Clinical Electrophysiology is one of a family of specialist journals launched by the renowned Journal of the American College of Cardiology (JACC). It encompasses all aspects of the epidemiology, pathogenesis, diagnosis and treatment of cardiac arrhythmias. Submissions of original research and state-of-the-art reviews from cardiology, cardiovascular surgery, neurology, outcomes research, and related fields are encouraged. Experimental and preclinical work that directly relates to diagnostic or therapeutic interventions are also encouraged. In general, case reports will not be considered for publication.
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