ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Mete Pekdiker, Sertaç Ketenci
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Abstract

Vaccines are an identified cause of autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In this research, we aimed to investigate the remarkable features of patients, whom we classified as ASIA syndrome, developing rheumatoid arthritis (RA) after BNT162b2 vaccination. Patients who were asymptomatic before the BNT162b2 vaccination, developed chronic arthritis within 3 months after the vaccination, and fulfilled the 2010 American College of Rheumatology/European League Against Rheumatism RA classification criteria were enrolled in the study. Demographic, laboratory, clinical, and treatment characteristics were reviewed retrospectively. We identified ten patients developing RA following BNT162b2 vaccination. The median age was 54.5 years and six of them were female. The median time between vaccination and onset of symptoms was 7 days; seven patients had acute arthritis, and four had intermittent arthritis at the onset of the disease. Only three patients had a disease onset in the small joints of the hands. All patients had radiological erosions on hand X-rays. We reported a case series of patients, classifiable as having ASIA syndrome, who developed RA with radiological erosions after the BNT162b2 vaccine. The onset of the disease in joints different from the typically expected ones, along with the early development of erosions in hand X-rays, suggests that these cases may follow a course distinct from classic RA. RA that develops following mRNA vaccination may have an aggressive course, but studies with larger sample sizes are needed.

Abstract Image

接种 BNT162b2 疫苗后的 ASIA 综合征:它是一种独特的类风湿性关节炎表型吗?
疫苗是佐剂诱导的自身免疫/炎症综合征(ASIA 综合征)的一个公认病因。在这项研究中,我们旨在调查被归类为 ASIA 综合征的患者在接种 BNT162b2 疫苗后出现类风湿性关节炎(RA)的显著特征。研究招募了接种 BNT162b2 疫苗前无症状、接种疫苗后 3 个月内出现慢性关节炎并符合 2010 年美国风湿病学会/欧洲抗风湿病联盟 RA 分类标准的患者。我们对患者的人口统计学特征、实验室特征、临床特征和治疗特征进行了回顾性分析。我们发现有 10 名患者在接种 BNT162b2 疫苗后出现了 RA。中位年龄为 54.5 岁,其中 6 人为女性。从接种疫苗到出现症状的中位时间为 7 天;7 名患者出现急性关节炎,4 名患者在发病时出现间歇性关节炎。只有三名患者的发病部位是手部小关节。所有患者的手部 X 光片均有放射性侵蚀。我们报告了一系列可归类为ASIA综合征的患者病例,他们在接种BNT162b2疫苗后出现了伴有放射性侵蚀的RA。发病关节与通常预期的关节不同,而且手部X光片早期出现侵蚀,这表明这些病例的病程可能有别于典型的RA。接种mRNA疫苗后出现的RA病程可能具有侵袭性,但还需要进行样本量更大的研究。
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来源期刊
Immunologic Research
Immunologic Research 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.
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