Neural correlates of phantom motor execution: A functional neuroimaging systematic review and meta-analysis

IF 3.2 2区心理学 Q1 BEHAVIORAL SCIENCES

Cortex Pub Date : 2024-12-01 DOI:10.1016/j.cortex.2024.09.001

Kevin Pacheco-Barrios , Robin Emily Heemels , Daniela Martinez-Magallanes , Marianna Daibes , Cristina Naqui-Xicota , Maria Andrade , Felipe Fregni

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引用次数: 0

Abstract

Phantom motor execution (PME) shows promise as a new treatment for phantom limb pain (PLP) by inducing motor-related analgesia and retraining the pain network activation. However, the current understanding of the neural correlates underlying PME is limited. Databases were systematically searched for multimodal neuroimaging studies to explore the neural correlates of PME. A narrative synthesis (17 studies, n = 328) and coordinate-based meta-analysis were performed to identify activation commonalities. Contrasting PME-vs-REST revealed differential activation of the supplementary motor area (SMA), post-central gyrus, and dorsolateral superior frontal gyrus; while PME-vs-ME revealed differential activation of the right anterior insula, anterior cingulate, left amygdala, and right striatum. Further narrative synthesis revealed a positive correlation between PME-induced brain activity and PLP intensity, and a specific connectivity pattern during PME on the SMA–M1 network compared to ME and motor imagery. Our results suggest that the PME represents a distinct type of motor network activation, partially overlapping with ME and motor imagery activations but with special activation of interoceptive regulation and mood-related regions. Thus, confirming its potential as a therapeutic approach for PLP.

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幻影运动执行的神经相关性：功能神经成像系统回顾与荟萃分析

幻肢运动执行（PME）通过诱导与运动相关的镇痛和重新训练疼痛网络激活，有望成为一种治疗幻肢痛（PLP）的新方法。然而，目前人们对 PME 的神经相关性的了解还很有限。我们在数据库中系统地搜索了多模态神经影像学研究，以探索 PME 的神经相关性。研究人员进行了叙述性综合（17 项研究，= 328）和基于坐标的荟萃分析，以确定激活的共性。PME-vs-REST对比显示了辅助运动区（SMA）、后中央回和背外侧额上回；而PME-vs-ME则显示了右侧前脑岛、前扣带回、左侧杏仁核和右侧纹状体的不同激活。进一步的叙事综合显示，PME 引起的大脑活动与 PLP 强度之间存在正相关，与 ME 和运动想象相比，PME 期间 SMA-M1 网络存在特定的连接模式。我们的研究结果表明，PME 代表了一种不同类型的运动网络激活，与 ME 和运动想象激活有部分重叠，但对感知调节和情绪相关区域有特殊激活。因此，这证实了它作为 PLP 治疗方法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cortex 医学-行为科学

CiteScore

7.00

自引率

5.60%

发文量

250

审稿时长

74 days

期刊介绍： CORTEX is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi.