Impacts of different hydrotropes on the aggregation behavior and physicochemical parameters of sodium dodecyl sulfate and ofloxacin drug mixture at several temperatures

IF 2.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2024-09-13 DOI:10.1007/s00396-024-05317-z

Bulbul Ahmed, Javed Masood Khan, Shamim Mahbub, Hossain M. Shahadat, Dileep Kumar, Manoj Kumar Banjare, Tajmul Hasan, Shahed Rana, Md. Anamul Hoque

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Abstract

The study of the aggregation of anionic surfactant, sodium dodecyl sulfate (SDS) with an antibiotic drug, ofloxacin (OFC) has been performed employing conductivity measurement technique in different aq. hydrotropes (HDTs) media. The aqueous solutions of four HDTs (two anionic HDTs (sodium benzoate (NaBenz) and sodium salicylate (NaSal)) and two non-ionic HDTs (p-aminobenzoic acid (PABA) and resorcinol (ReSC))), having different compositions, were used to investigate their effect on the micellization phenomena of the SDS + OFC mixture. The micelle formation of the SDS + OFC mixture has been detected to be reliant on the nature and composition of additives as well as the temperature variation. At lower concentration (1.00 mmol kg⁻¹) of HDTs in aq. media, the CMC values of the working system followed the following order: CMC_PABA > CMC_NaBenz > CMC_ReSC > CMC_NaSal, and the CMC values increased with the rising concentration of HDTs. An increase in temperature at a fixed composition of OFC and HDTs resulted in the elevation of CMC values. The extent of counterion binding (β) values exhibited to be reduced with an increase of both concentration of HDTs and temperature. The negative free energy change (\({\Delta G}_{m}^{0}\)) for the micellization processes across all temperatures and investigated media indicates spontaneous micellization. The enthalpy change (\({\Delta H}_{m}^{0}\)) of micellization of the SDS + OFC mixture was obtained to be positive (endothermic) and negative (exothermic) at lower and higher temperatures in all media studied. The entropy change \({(\Delta S}_{m}^{0}\)) of micellization is positive even with varying temperatures in all the working additive media. The molar heat capacity (\({\Delta C}_{m,p}^{0}\)), transfer properties, and enthalpy-entropy compensation have been evaluated and explained with appropriate reasoning for the examined systems.

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不同水托对十二烷基硫酸钠和氧氟沙星药物混合物在不同温度下的聚集行为和理化参数的影响

利用电导率测量技术，在不同的水合介质（HDTs）中对阴离子表面活性剂十二烷基硫酸钠（SDS）与抗生素药物氧氟沙星（OFC）的聚集进行了研究。研究使用了四种不同成分的 HDTs（两种阴离子 HDTs（苯甲酸钠（NaBenz）和水杨酸钠（NaSal））和两种非离子 HDTs（对氨基苯甲酸（PABA）和间苯二酚（ReSC）））水溶液来研究它们对 SDS + OFC 混合物胶束化现象的影响。结果发现，SDS + OFC 混合物的胶束形成与添加剂的性质和成分以及温度变化有关。在低浓度（1.00 mmol kg-1）HDTs 的水溶液介质中，工作系统的 CMC 值按以下顺序排列：CMCPABA>；CMCNaBenz>；CMCReSC>；CMCNaSal。在 OFC 和 HDT 成分固定的情况下，温度升高会导致 CMC 值升高。随着 HDTs 浓度和温度的升高，反离子结合程度（β）值也随之降低。在所有温度和研究介质中，胶束化过程的负自由能变化（{\Δ G}_{m}^{0}\）表明胶束化是自发的。在研究的所有介质中，SDS + OFC 混合物胶束化的焓变 (\({\Delta H}_{m}^{0}\)) 在较低和较高温度下分别为正（内热）和负（放热）。在所有工作添加剂介质中，即使温度不同，胶化的熵变（{(\Delta S}_{m}^{0}/)）也是正的。摩尔热容（\({\Delta C}_{m,p}^{0}/））、传递特性和焓熵补偿都得到了评估，并用适当的推理解释了所研究体系。

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.