Investigating Working Memory Deficits in School-Age Children with Attention-Deficit/Hyperactivity Disorder: An Event-Related Potentials Study During Delayed-Match-to-Sample Task

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2024-09-18 DOI:10.1177/10870547241277521

I-Hsuan Shen, Wei-En Wang, Hsing-Chang Ni, Chia-Ling Chen

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引用次数: 0

Abstract

Objective:To investigate the neural mechanisms underlying working memory (WM) deficits in children with ADHD.Method:WM was compared between thirty-four children with ADHD and thirty-four matched controls using neuropsychological tests, spatial and verbal versions of modified delayed matching-to-sample (DMTS) tasks, and the event-related potential technique.Results:Children with ADHD demonstrated poor behavioral performance, delayed P3 latencies in high-load spatial modified DMTS tasks during encoding, and delayed P2 and N2 latencies during retrieval in spatial modified DMTS tasks. In high-load verbal modified DMTS tasks during encoding, they showed a smaller P3 amplitude.Discussion:Pronounced deficits in the central executive system in children with ADHD were exhibited by neuropsychological tests and the modified DMTS task. Children with ADHD exhibited a slowing of processing speed during encoding. Under high-load conditions, they showed a reduced P3 amplitude during retrieval, suggesting reduced neural resource allocation was available when the central executive of the working memory was heavily loaded.

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调查学龄期注意力缺陷/多动障碍儿童的工作记忆缺陷：延迟匹配到样本任务中的事件相关电位研究

结果：多动症儿童的行为表现较差，在高负荷空间改良DMTS任务中，编码时P3潜伏期延迟，在空间改良DMTS任务中，检索时P2和N2潜伏期延迟。讨论：神经心理测试和改良DMTS任务显示，多动症儿童的中枢执行系统存在明显缺陷。多动症儿童在编码过程中表现出处理速度减慢。在高负荷条件下，他们在检索时的P3振幅减小，这表明当工作记忆的中央执行系统负荷过重时，神经资源分配减少。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.