Chlorine‐Thymol Substituted Silicon (IV) Phthalocyanines: Synthesis, Characterization, and In Vitro Acetylcholinesterase (AChE)/Butyrylcholinesterase (BChE) Inhibitory Effect

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2024-09-14 DOI:10.1002/aoc.7757

Ayse Aktas Kamiloglu, Tayfun Arslan, Askın Tekin, Halit Kantekin, Irfan Acar

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引用次数: 0

Abstract

In this study, novel chlorine‐thymol derivatives (1,3‐bis(4‐chloro‐2‐isopropyl‐5 methylphenoxy)propan‐2‐ol (Thy‐OHI) and 2‐[2‐(4‐chloro‐2‐isopropyl‐5‐methylphenoxy)ethoxy]ethanol (Thy‐OHII)) and axially di‐4‐chloro‐2‐isopropyl‐5‐methylphenoxy (Thy‐SiPc), 1,3‐bis(4‐chloro‐2‐isopropyl‐5‐methylphenoxy)propanoxy (Thy‐OHI‐SiPc), and 2‐[2‐(4‐chloro‐2‐isopropyl‐5‐methylphenoxy)ethoxy]ethanoxy (Thy‐OHII‐SiPc) substituted silicon phthalocyanine compounds were obtained, and their structures were elucidated by the combination of various methods such as NMR, IR, UV–Vis, and MS. The inhibitory effects of these compounds (Thy‐OHI, Thy‐OHII, Thy‐SiPc, Thy‐OHI‐SiPc and Thy‐OHII‐SiPc), synthesized for the first time, on cholinesterase enzymes (AChE and BChE) were investigated in the laboratory environment. In the studies, notably Thy‐OHI‐Si and thymol derivative ligand Thy‐OHII displayed significant inhibition against AChE and BChE.

Abstract Image

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氯-甲基取代硅 (IV) 酞菁：合成、表征和体外乙酰胆碱酯酶（AChE）/丁酰胆碱酯酶（BChE）抑制作用

在这项研究中，新型氯-百里酚衍生物（1,3-双（4-氯-2-异丙基-5-甲基苯氧基）丙-2-醇（Thy-OHI）和 2-[2-（4-氯-2-异丙基-5-甲基苯氧基）乙氧基]乙醇（Thy-OHII））以及轴向二-4-氯-2-异丙基-5-甲基苯氧基（Thy-SiPc）、1、结合核磁共振、红外光谱、紫外可见光谱和质谱等多种方法阐明了它们的结构。在实验室环境中研究了这些首次合成的化合物（Thy-OHI、Thy-OHII、Thy-SiPc、Thy-OHI-SiPc 和 Thy-OHII-SiPc）对胆碱酯酶（AChE 和 BChE）的抑制作用。研究发现，Thy-OHI-Si 和百里酚衍生物配体 Thy-OHII 对 AChE 和 BChE 有明显的抑制作用。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.