Effect of central dialysis fluid delivery system on markers of inflammation in hemodialysis patients

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY

BMC Nephrology Pub Date : 2024-09-19 DOI:10.1186/s12882-024-03751-3

Yanhong Ni, Wenhui Wu, Hua Zhou, Min Li, Xiying Zhu, Hongyan Niu, Jinfeng Liu, Lina Xue, Yeqian Liu, Min Yang

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引用次数: 0

Abstract

The utilization of ultrapure dialysate has been shown to decrease dialysate contamination and mitigate inflammatory responses. The central dialysate delivery system (CDDS) has the potential to attain a level of purity similar to ultrapure dialysate. Nevertheless, there is limited research examining the impact of CDDS on inflammation in comparison to single-patient dialysis fluid delivery system(SPDDS). This study aims to investigate the effects of CDDS utilizing ultrapure dialysate on ameliorating the microinflammatory state in hemodialysis patients. A retrospective cohort clinical study enrolled a total of 125 hemodialysis patients, with 58 patients from the CDDS unit and 67 patients from the SPDDS unit. Each participant was monitored for a period of 6 months, and the repeated measurement data was analyzed using a generalized linear mixed models (GLMM). The average age of the studty cohort was 56.22 ± 12.64 years. The GLMM analysis showed a significant time*group interaction effect on hs-CRP changes over the follow-up period (β = -1.966, FTime* CDDS group = 13.389, P < 0.001). A linear mixed model analysis with random slope showed that a different slope was observed between CDDS group and SPDDS group (βCDDS =—0.793; βSPDDS = 0.791), indicating a decreased hs-CRP levels in CDDS group, while increased in the SPDDS group over the follow-up period. However, no significant time*group interaction effect were observed on albumin and β2-microglobulin levels during follow-up period(β2-microglobulin: β = -0.658, FTime* CDDS group = 1.228, P = 0.269; albumin: β = 0.012, FTime* CDDS group = 1.429, P = 0.233). Using ultrapure dialysate in the CDDS is associated with an improvement in hs-CRP levels compared to standard dialysate, which might confer long-term clinical advantages.

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中央透析输液系统对血液透析患者炎症指标的影响

事实证明，使用超纯透析液可以减少透析液污染，减轻炎症反应。中央透析液输送系统（CDDS）有可能达到与超纯透析液类似的纯度。然而，与单病种透析液输送系统（SPDDS）相比，有关 CDDS 对炎症影响的研究还很有限。本研究旨在探讨使用超纯透析液的 CDDS 对改善血液透析患者微炎症状态的影响。这项回顾性队列临床研究共招募了 125 名血液透析患者，其中 58 名患者来自 CDDS 单位，67 名患者来自 SPDDS 单位。对每位参与者进行了为期 6 个月的监测，并使用广义线性混合模型（GLMM）对重复测量数据进行了分析。研究队列的平均年龄为 56.22 ± 12.64 岁。GLMM 分析显示，在随访期间，时间*组对 hs-CRP 变化有显著的交互影响（β = -1.966, FTime* CDDS 组 = 13.389, P < 0.001）。随机斜率线性混合模型分析显示，CDDS组与SPDDS组的斜率不同（βCDDS=-0.793；βSPDDS=0.791），表明随访期间CDDS组的hs-CRP水平下降，而SPDDS组上升。然而，在随访期间，白蛋白和β2-微球蛋白水平没有观察到明显的时间*组交互效应（β2-微球蛋白：β = -0.658，FTime* CDDS 组 = 1.228，P = 0.269；白蛋白：β = 0.012，FTime* CDDS 组 = 1.429，P = 0.233）。与标准透析液相比，在 CDDS 中使用超纯透析液可改善 hs-CRP 水平，这可能会带来长期的临床优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.