When Oxybutynin Becomes a Decoy for Oxycodone: A Case Report of Diversion Through Substitution

IF 2.6 3区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Drug Testing and Analysis Pub Date : 2024-09-17 DOI:10.1002/dta.3802

Ricardo E. Verdiner, Alissa Voils, Lynsey Seim, Krystal Koball, Maxwell Verdiner, Aram Mardian, Adam J. Milam

引用次数: 0

Abstract

This case report describes the novel use of oxybutynin and acetaminophen as a substitution for oxycodone for the express purpose of diverting oxycodone in a hospital‐based post‐anesthesia care unit (PACU). The report outlines how the physical properties and pharmacologic effects of non‐controlled medications in the PACU, like oxybutynin, can be visually mistaken and even mimic the side effects of controlled substances like oxycodone. Substituting oxybutynin for controlled substances can circumvent diversion surveillance software. The authors describe how the diversion was identified and the process improvements that should be implemented for proactive identification moving forward.

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当奥昔布宁成为奥昔可酮的诱饵时：通过替代品转移用途的案例报告

本病例报告描述了在医院麻醉后护理病房（PACU）中使用奥昔布宁和对乙酰氨基酚作为羟考酮替代品的新情况，其明确目的是转移羟考酮。报告概述了 PACU 中非管制药物（如羟丁宁）的物理性质和药理作用如何被误认为甚至模仿受管制药物（如羟考酮）的副作用。用奥昔布宁代替受管制药物可以规避转移监控软件。作者介绍了如何识别出转移用途的情况，以及今后在主动识别方面应实施的流程改进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Testing and Analysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

5.90

自引率

24.10%

发文量

191

审稿时长

2.3 months

期刊介绍： As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances. In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds). Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.