Endothelial glycocalyx degradation in critically ill foals

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2024-09-14 DOI:10.1111/jvim.17196

Diego E. Gomez, Ahmed Kamr, William F. Gilsenan, Teresa A. Burns, M. C. Mudge, Laura D. Hostnik, Ramiro E. Toribio

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引用次数: 0

Abstract

Background

Endothelial glycocalyx (EG) degradation occurs in septic humans and EG products can be used as biomarkers of endothelial injury. Information about EG biomarkers and their association with disease severity is lacking in hospitalized foals.

Objectives

Measure serum syndecan-1 (SDC-1), heparan sulfate (HS), angiopoietin-2 (ANG-2), aldosterone (ALD), and plasma atrial natriuretic peptide (ANP) concentrations and to determine their association with disease severity and death in hospitalized foals.

Animals

Ninety foals ≤3 days old.

Methods

Prospective, multicenter, longitudinal study. Foals were categorized into hospitalized (n = 74; 55 septic; 19 sick nonseptic) and 16 healthy foals. Serum ([SDC-1], [HS], [ANG-2], [ALD]) and plasma (ANP) were measured over 72 hours using immunoassays.

Results

Serum ([SDC-1], [HS], [ANG-2], [ALD]) and plasma (ANP) were significantly higher in hospitalized and septic than healthy foals (P < .05). Serum (ANG-2) and plasma (ANP) were significantly higher in hospitalized nonsurvivors than in survivors (P < .05). On admission, hospitalized foals with serum (HS) > 58.7 ng/mL had higher odds of nonsurvival (odds ratio [OR] = 6.1; 95% confidence interval [CI] = 1.02-36.7). Plasma (ANP) >11.5 pg/mL was associated with the likelihood of nonsurvival in hospitalized foals (OR = 7.2; 95% CI = 1.4-37.4; P < .05). Septic foals with serum (ANG-2) >1018 pg/mL on admission had higher odds of nonsurvival (OR = 6.5; 95% CI =1.2-36.6; P < .05).

Conclusion and Clinical Importance

Critical illness in newborn foals is associated with EG degradation and injury, and these biomarkers are related to the severity of disease on admission and the outcome of sick foals.

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重症马驹的内皮糖萼降解

背景脓毒症患者的内皮糖萼（EG）会发生降解，EG产物可作为内皮损伤的生物标志物。目前还缺乏住院马驹的 EG 生物标志物及其与疾病严重程度的关系的相关信息。目的测量住院小马驹的血清辛迪加-1（SDC-1）、硫酸肝素（HS）、血管生成素-2（ANG-2）、醛固酮（ALD）和血浆心房利钠肽（ANP）浓度，并确定它们与疾病严重程度和死亡的关系。小马驹被分为住院小马驹（n = 74；55 患化脓性疾病；19 患非化脓性疾病）和 16 只健康小马驹。结果住院和败血症小马驹的血清（[SDC-1]、[HS]、[ANG-2]、[ALD]）和血浆（ANP）显著高于健康小马驹（P <.05）。非存活的住院马驹的血清（ANG-2）和血浆（ANP）明显高于存活马驹（P < .05）。入院时，血清（HS）> 58.7 ng/mL的住院马驹非存活几率更高（几率比 [OR] = 6.1; 95% 置信区间 [CI] = 1.02-36.7）。血浆（ANP）>11.5 pg/mL与住院马驹的非存活几率有关（OR = 7.2；95% CI = 1.4-37.4；P <.05）。入院时血清（ANG-2）>1018 pg/mL的化脓性小马驹非存活几率更高（OR = 6.5; 95% CI = 1.2-36.6; P <.05）。结论和临床意义新生小马驹的危重病与EG降解和损伤有关，这些生物标志物与入院时的疾病严重程度和病驹的预后有关。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.