Regenerated nanofibrous cellulose electrospun from ionic liquid: Tuning properties toward tissue engineering.

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part A Pub Date : 2024-09-19 DOI:10.1002/jbm.a.37798

Ingrida Pauliukaitytė,Darius Čiužas,Edvinas Krugly,Odeta Baniukaitienė,Mindaugas Bulota,Vilma Petrikaitė,Dainius Martuzevičius

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Abstract

Regenerated fibrous cellulose possesses a unique set of properties, including biocompatibility, biodegradability, and high surface area potential, but its applications in the biomedical sector have not been sufficiently explored. In this study, nanofibrous cellulose matrices were fabricated via a wet-electrospinning process using a binary system of the solvent ionic liquid (IL) 1-butyl-3-methylimidazolium acetate (BMIMAc) and co-solvent dimethyl sulfoxide (DMSO). The morphology of the matrices was controlled by varying the ratio of BMIMAc versus DMSO in the solvent system. The most effective ratio of 1:1 produced smooth fibers with diameters ranging from 200 to 400 nm. The nanofibrous cellulose matrix showed no cytotoxicity when tested on mouse fibroblast L929 cells whose viability remained above 95%. Human triple-negative breast cancer MDA-MB-231 cells also exhibited high viability even after 7 days of seeding and were able to penetrate deeper layers of the matrix, indicating high biocompatibility. These properties of nanofibrous cellulose demonstrate its potential for tissue engineering and cell culture applications.

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离子液体电纺再生纳米纤维素：调整组织工程特性。

再生纤维素具有一系列独特的特性，包括生物相容性、生物可降解性和高表面积潜力，但其在生物医学领域的应用尚未得到充分探索。在本研究中，采用溶剂离子液体（IL）1-丁基-3-甲基咪唑醋酸酯（BMIMAc）和助溶剂二甲基亚砜（DMSO）的二元体系，通过湿法电纺丝工艺制备了纳米纤维素基质。通过改变 BMIMAc 与 DMSO 在溶剂系统中的比例来控制基质的形态。最有效的比例为 1:1，可生成直径为 200 至 400 纳米的光滑纤维。在对小鼠成纤维细胞 L929 进行测试时，纳米纤维素基质没有显示出细胞毒性，其存活率保持在 95% 以上。人类三阴性乳腺癌 MDA-MB-231 细胞在播种 7 天后也表现出很高的存活率，并能穿透基质的深层，这表明它具有很高的生物相容性。纳米纤维素的这些特性证明了它在组织工程和细胞培养应用方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part A 工程技术-材料科学：生物材料

CiteScore

10.40

自引率

2.00%

发文量

135

审稿时长

3.6 months

期刊介绍： The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.