Optical coherence tomography angiography enables visualization of microvascular patterns in chronic venous insufficiency

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-09-20 DOI:10.1016/j.isci.2024.110998

Giulia Rotunno, Julia Deinsberger, Kristen M. Meiburger, Lisa Krainz, Lukasz Bugyi, Valentin Hacker, Richard Haindl, Rainer Leitgeb, Christoph Sinz, Leopold Schmetterer, Wolfgang Drexler, Benedikt Weber, Mengyang Liu

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Abstract

Chronic venous insufficiency (CVI) is a global health concern with significant public health and individual impact. Currently available diagnostic methods cannot visualize microvenous pathologies that have shown to result in severe forms of CVI and also affect the skin. Optical coherence tomography angiography (OCTA) may close the CVI diagnostic gap by providing a fast, label-free, and non-invasive solution to visualize cutaneous microvasculature. The study enlisted 66 subjects, including 53 CVI patients spanning all clinical-etiology-anatomic-pathophysiologic (CEAP) C stages and 13 healthy controls. The high spatial resolution OCTA system used was specifically designed for skin imaging. Significant microangiographic pattern variations emerged, both in qualitative and quantitative terms. OCTA provided valuable insights into cutaneous microvascular changes among different CVI stages. Thereby, OCTA may enable the selection of patient populations at risk for disease progression in the future.

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光学相干断层血管造影术可观察慢性静脉功能不全的微血管形态

慢性静脉功能不全（CVI）是一个全球性的健康问题，对公共卫生和个人都有重大影响。目前可用的诊断方法无法观察到微静脉病变，而这些病变已被证明会导致严重形式的 CVI，而且还会影响皮肤。光学相干断层血管成像（OCTA）可提供快速、无标记、无创的皮肤微血管可视化解决方案，从而弥补 CVI 诊断方面的不足。该研究征集了 66 名受试者，包括 53 名跨越所有临床-病因-解剖-病理生理（CEAP）C 阶段的 CVI 患者和 13 名健康对照者。所使用的高空间分辨率 OCTA 系统专为皮肤成像而设计。在定性和定量方面都出现了显著的微血管形态变化。OCTA 为了解不同 CVI 阶段的皮肤微血管变化提供了宝贵的信息。因此，OCTA 可以帮助选择未来面临疾病进展风险的患者人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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