Optimized green synthesis of biocompatible Ag nanostructures using Artemisia Indica leaf extract: a promising avenue for biomedical applications

IF 1.6 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Transition Metal Chemistry Pub Date : 2024-09-18 DOI:10.1007/s11243-024-00608-4

Manoj Manikrao Gadewar, G. K Prashanth, Srilatha Rao, H. S. Lalithamba, N. P. Bhagya, A. S. Sowmyashree, K. Shwetha, Hemantkumar N. Akolkar

{"title":"Optimized green synthesis of biocompatible Ag nanostructures using Artemisia Indica leaf extract: a promising avenue for biomedical applications","authors":"Manoj Manikrao Gadewar, G. K Prashanth, Srilatha Rao, H. S. Lalithamba, N. P. Bhagya, A. S. Sowmyashree, K. Shwetha, Hemantkumar N. Akolkar","doi":"10.1007/s11243-024-00608-4","DOIUrl":null,"url":null,"abstract":"<p><i>Artemisia indica,</i> belonging to the family Asteraceae, is renowned for its rich phytoconstituents and traditional medicinal uses. This study aimed to optimize the green synthesis of biocompatible Ag NPs using varying concentrations of <i>A. indica</i> leaf extract and AgNO3. The objectives were to characterize the synthesized NPs and evaluate their potential biomedical applications. The synthesized NPs were characterized using FTIR, XRD, TEM, and Zeta sizer. The results indicated an average particle size of approximately 20 nm and a zeta potential of −23.4 mV, confirming their stability. PXRD analysis demonstrated the crystalline nature of the NPs, while FTIR analysis confirmed the capping of phytoconstituents on the nanoparticle surface. Biocompatibility was assessed using the MTT assay on the L929 cell line, showing 83% cell viability, indicating non-toxicity. Additionally, the green-synthesized NPs exhibited significant antibacterial activity at a concentration of 500 μg/mL, as evidenced by a clear zone of inhibition. This study highlights a rapid, eco-friendly synthesis method for Ag NPs, paving the way for novel biomedical applications.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11243-024-00608-4","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

Abstract

Artemisia indica, belonging to the family Asteraceae, is renowned for its rich phytoconstituents and traditional medicinal uses. This study aimed to optimize the green synthesis of biocompatible Ag NPs using varying concentrations of A. indica leaf extract and AgNO3. The objectives were to characterize the synthesized NPs and evaluate their potential biomedical applications. The synthesized NPs were characterized using FTIR, XRD, TEM, and Zeta sizer. The results indicated an average particle size of approximately 20 nm and a zeta potential of −23.4 mV, confirming their stability. PXRD analysis demonstrated the crystalline nature of the NPs, while FTIR analysis confirmed the capping of phytoconstituents on the nanoparticle surface. Biocompatibility was assessed using the MTT assay on the L929 cell line, showing 83% cell viability, indicating non-toxicity. Additionally, the green-synthesized NPs exhibited significant antibacterial activity at a concentration of 500 μg/mL, as evidenced by a clear zone of inhibition. This study highlights a rapid, eco-friendly synthesis method for Ag NPs, paving the way for novel biomedical applications.

Graphical Abstract

Abstract Image

查看原文本刊更多论文

利用印度蒿叶提取物优化生物相容性银纳米结构的绿色合成：生物医学应用的一个前景广阔的途径

蒿属植物因其丰富的植物成分和传统药用价值而闻名于世。本研究旨在利用不同浓度的茵陈蒿叶提取物和 AgNO3 优化生物相容性 Ag NPs 的绿色合成。目的是对合成的 NPs 进行表征，并评估其潜在的生物医学应用。使用傅立叶变换红外光谱、X射线衍射、TEM和Zeta测定仪对合成的NPs进行了表征。结果表明，其平均粒径约为 20 纳米，Zeta 电位为 -23.4 mV，证实了其稳定性。PXRD 分析表明了纳米粒子的结晶性质，而 FTIR 分析则证实了纳米粒子表面的植物成分。使用 MTT 法对 L929 细胞系进行了生物相容性评估，结果显示细胞存活率为 83%，表明纳米粒子无毒性。此外，绿色合成的 NPs 在浓度为 500 μg/mL 时表现出显著的抗菌活性，明显的抑菌区证明了这一点。这项研究强调了一种快速、环保的银氧化物合成方法，为新型生物医学应用铺平了道路。图文摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Transition Metal Chemistry 化学-无机化学与核化学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc. Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.