Application of nanozymes in problematic biofilm control: progress, challenges and prospects

IF 6.1 2区 环境科学与生态学 Q2 ENGINEERING, ENVIRONMENTAL
Junzheng Zhang, Tong Dou, Yun Shen, Wenrui Wang, Luokai Wang, Xuanhao Wu, Meng Zhang, Dongsheng Wang, Pingfeng Yu
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引用次数: 0

Abstract

Current microbial control strategies face challenges in keeping up with the escalation of microbial problems due to the presence of biofilms. Therefore, there is an urgent need to develop effective and robust strategies to control problematic biofilms in water treatment and reuse systems. Nanozymes, which have intrinsic biocatalytic activity and broad antibacterial spectra, hold promise for controlling resilient biofilms. This review summarizes the milestones of nanozyme studies and their applications as antibiofilm agents. The mechanisms behind the antibacterial, quorum quenching, and depolymerizing properties of nanozymes with different enzyme activities are discussed. Notably, the surface and composition of nanozymes are crucial for their efficacy in biofilm control; thus, rationally designed nanozymes can increase their effectiveness. Additionally, the challenges of nanozymes as antibiofilm agents in realistic scenarios are investigated along with proposed strategies to overcome these challenges. Prospects of nanozyme-based biofilm control, such as machine learning-assisted nanozyme design, are also discussed. Overall, this review highlights the potential of nanozymes as antibiofilm agents and provides insights into the future design of nanozymes for biofilm control.

Abstract Image

纳米酶在问题生物膜控制中的应用:进展、挑战和前景
由于生物膜的存在,目前的微生物控制策略在应对不断升级的微生物问题方面面临挑战。因此,迫切需要开发有效而稳健的策略,以控制水处理和回用系统中存在问题的生物膜。纳米酶具有内在的生物催化活性和广泛的抗菌谱,有望控制有弹性的生物膜。本综述总结了纳米酶研究的里程碑及其作为抗生物膜剂的应用。文中讨论了具有不同酶活性的纳米酶的抗菌、阙如和解聚特性背后的机制。值得注意的是,纳米酶的表面和组成对其控制生物膜的功效至关重要;因此,合理设计纳米酶可提高其功效。此外,还研究了纳米酶作为抗生物膜制剂在实际应用中面临的挑战,并提出了克服这些挑战的策略。还讨论了基于纳米酶的生物膜控制的前景,如机器学习辅助纳米酶设计。总之,本综述强调了纳米酶作为抗生物膜剂的潜力,并为未来设计用于生物膜控制的纳米酶提供了见解。
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来源期刊
Frontiers of Environmental Science & Engineering
Frontiers of Environmental Science & Engineering ENGINEERING, ENVIRONMENTAL-ENVIRONMENTAL SCIENCES
CiteScore
10.90
自引率
12.50%
发文量
988
审稿时长
6.1 months
期刊介绍: Frontiers of Environmental Science & Engineering (FESE) is an international journal for researchers interested in a wide range of environmental disciplines. The journal''s aim is to advance and disseminate knowledge in all main branches of environmental science & engineering. The journal emphasizes papers in developing fields, as well as papers showing the interaction between environmental disciplines and other disciplines. FESE is a bi-monthly journal. Its peer-reviewed contents consist of a broad blend of reviews, research papers, policy analyses, short communications, and opinions. Nonscheduled “special issue” and "hot topic", including a review article followed by a couple of related research articles, are organized to publish novel contributions and breaking results on all aspects of environmental field.
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