{"title":"Application of nanozymes in problematic biofilm control: progress, challenges and prospects","authors":"Junzheng Zhang, Tong Dou, Yun Shen, Wenrui Wang, Luokai Wang, Xuanhao Wu, Meng Zhang, Dongsheng Wang, Pingfeng Yu","doi":"10.1007/s11783-024-1896-0","DOIUrl":null,"url":null,"abstract":"<p>Current microbial control strategies face challenges in keeping up with the escalation of microbial problems due to the presence of biofilms. Therefore, there is an urgent need to develop effective and robust strategies to control problematic biofilms in water treatment and reuse systems. Nanozymes, which have intrinsic biocatalytic activity and broad antibacterial spectra, hold promise for controlling resilient biofilms. This review summarizes the milestones of nanozyme studies and their applications as antibiofilm agents. The mechanisms behind the antibacterial, quorum quenching, and depolymerizing properties of nanozymes with different enzyme activities are discussed. Notably, the surface and composition of nanozymes are crucial for their efficacy in biofilm control; thus, rationally designed nanozymes can increase their effectiveness. Additionally, the challenges of nanozymes as antibiofilm agents in realistic scenarios are investigated along with proposed strategies to overcome these challenges. Prospects of nanozyme-based biofilm control, such as machine learning-assisted nanozyme design, are also discussed. Overall, this review highlights the potential of nanozymes as antibiofilm agents and provides insights into the future design of nanozymes for biofilm control.\n</p>","PeriodicalId":12720,"journal":{"name":"Frontiers of Environmental Science & Engineering","volume":"28 1","pages":""},"PeriodicalIF":6.1000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers of Environmental Science & Engineering","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1007/s11783-024-1896-0","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Current microbial control strategies face challenges in keeping up with the escalation of microbial problems due to the presence of biofilms. Therefore, there is an urgent need to develop effective and robust strategies to control problematic biofilms in water treatment and reuse systems. Nanozymes, which have intrinsic biocatalytic activity and broad antibacterial spectra, hold promise for controlling resilient biofilms. This review summarizes the milestones of nanozyme studies and their applications as antibiofilm agents. The mechanisms behind the antibacterial, quorum quenching, and depolymerizing properties of nanozymes with different enzyme activities are discussed. Notably, the surface and composition of nanozymes are crucial for their efficacy in biofilm control; thus, rationally designed nanozymes can increase their effectiveness. Additionally, the challenges of nanozymes as antibiofilm agents in realistic scenarios are investigated along with proposed strategies to overcome these challenges. Prospects of nanozyme-based biofilm control, such as machine learning-assisted nanozyme design, are also discussed. Overall, this review highlights the potential of nanozymes as antibiofilm agents and provides insights into the future design of nanozymes for biofilm control.
期刊介绍:
Frontiers of Environmental Science & Engineering (FESE) is an international journal for researchers interested in a wide range of environmental disciplines. The journal''s aim is to advance and disseminate knowledge in all main branches of environmental science & engineering. The journal emphasizes papers in developing fields, as well as papers showing the interaction between environmental disciplines and other disciplines.
FESE is a bi-monthly journal. Its peer-reviewed contents consist of a broad blend of reviews, research papers, policy analyses, short communications, and opinions. Nonscheduled “special issue” and "hot topic", including a review article followed by a couple of related research articles, are organized to publish novel contributions and breaking results on all aspects of environmental field.