Oral mucosal changes caused by nicotine pouches: case series

IF 2.4 3区医学 Q2 PATHOLOGY

Diagnostic Pathology Pub Date : 2024-09-19 DOI:10.1186/s13000-024-01549-3

Sintija Miluna-Meldere, Sarlote Agate Vanka, Ingus Skadins, Juta Kroica, Maris Sperga, Dagnija Rostoka

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引用次数: 0

Abstract

Oral nicotine pouches are the latest products in the tobacco industry. They are manufactured by large tobacco companies and entice tobacco or nicotine addicts, although the products are presented as a ‘harmless choice.’ Nevertheless, dentists and oral health specialists worry about oral mucosal changes due to product interactions with the oral mucosa. Unfortunately, there are no case reports of oral mucosal changes from nicotine pouches that are also investigated histopathologically. The aim of the present study was to visually and histopathologically investigate oral mucosal changes in nicotine pouch users. An online retrospective survey regarding medical and dental health, dietary habits, and tobacco consumption habits was conducted (n = 50). Respondents were selected for further intraoral and histopathological investigation based on the inclusion criteria. All five respondents had oral lesions that were histopathologically analyzed. Visually, the lesions varied in form and intensity, but all appeared white at the location where the pouches were placed. Histopathological analyses revealed parakeratosis with acanthotic epithelium, intraepithelial and connective tissue oedema, and chronic inflammatory infiltration with lymphocytes and macrophages. Participants received information about nicotine cessation and oral health recommendations. In conclusion, nicotine pouches significantly impacted oral mucosa with white lesions that revealed important changes at the cellular level.

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尼古丁袋引起的口腔黏膜变化：病例系列

口服尼古丁袋是烟草行业的最新产品。它们由大型烟草公司生产，诱使烟草或尼古丁上瘾，尽管这些产品被说成是 "无害的选择"。然而，牙医和口腔健康专家担心产品与口腔黏膜的相互作用会导致口腔黏膜发生变化。遗憾的是，目前还没有关于尼古丁袋导致口腔黏膜变化的病例报告，也没有对其进行组织病理学调查。本研究旨在对尼古丁袋使用者的口腔黏膜变化进行视觉和组织病理学调查。研究人员就医疗和牙科健康、饮食习惯和烟草消费习惯进行了在线回顾性调查（n = 50）。根据纳入标准，受访者被选中进行进一步的口腔内和组织病理学调查。所有五名受访者都有口腔病变，并进行了组织病理学分析。从外观上看，病变的形式和强度各不相同，但在放置口腔袋的位置都呈现白色。组织病理学分析表明，副角化症伴有棘状上皮、上皮内和结缔组织水肿以及淋巴细胞和巨噬细胞的慢性炎症浸润。参与者收到了有关尼古丁戒断和口腔健康建议的信息。总之，尼古丁袋对口腔黏膜产生了显著影响，其白色病变显示了细胞层面的重要变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).