The decorin and myostatin response to acute whole body vibration: impact of adiposity, sex, and race

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2024-09-16 DOI:10.1038/s41366-024-01630-3

Morgan N. Broniec, Kimberly Norland, Jeffrey Thomas, Xiaoling Wang, Ryan A. Harris

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引用次数: 0

Abstract

Background

Traditional forms of exercise affect immune, metabolic, and myokine responses and contribute to a multitude of health benefits. Whole body vibration (WBV) has recently emerged as an exercise mimetic that may be more tolerable for those individuals that cannot perform traditional exercise. However, the myokines response to acute WBV in humans has yet to be fully elucidated.

Objective

To characterize the decorin and myostatin response to acute whole body vibration (WBV) and determine the impact of adiposity, sex, and race.

Subjects

One hundred twenty-nine adults (32.8 ± 0.4 years, 66.7% female, 53.5% non-Hispanic Black) were recruited as part of an ongoing, longitudinal twin cohort parent study. Participants were classified into three groups: those with obesity (OB: ≥30 kg/m²), those who are overweight (OW: ≥25 and <30 kg/m²), or those with normal weight (NW: <25 kg/m²) based on BMI.

Methods

Blood was collected at baseline (PRE), immediately post (POST), and 1 h (1H), 3 h (3H), and 24 h (24H) post WBV. The acute WBV protocol consisted of 10 cycles of 1 min of vibration exercise followed by 30 s of standing rest.

Results

The response was similar between NW and OW, so these groups were combined for analysis (NW/OW: BMI < 30 kg/m²). Overall, circulating concentrations of decorin were higher (p < 0.001) POST (8.80 ± 0.19 pg/mL) and significantly lower (p’s ≤ 0.005) at 1H (8.66 ± 0.19 pg/mL) and 3H (8.68 ± 0.19 pg/mL), compared to PRE (8.71 ± 0.19 pg/mL). Decorin POST was greater (p = 0.016) in the OB group (8.82 ± 0.18 pg/mL) compared to the NW/OW group (8.77 ± 0.20 pg/mL). Overall, myostatin was higher (p = 0.002) POST (54.93 ± 1.04 pg/mL) and lower (p < 0.001) at 24H (49.13 ± 1.04 pg/mL) compared to PRE (53.49 ± 1.04 pg/mL). The myostatin response was lower (p’s ≤ 0.001) in female and non-Hispanic White individuals compared to male and non-Hispanic Black individuals, respectively.

Conclusions

A single bout of WBV can facilitate the release of decorin and myostatin into circulation, a similar response to traditional exercise. Additionally, adiposity, sex and race should be considered when evaluating the myokines response to WBV.

Abstract Image

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对急性全身振动的去甲斑蝥素和肌节蛋白反应：脂肪、性别和种族的影响

背景传统形式的运动会影响免疫、新陈代谢和肌动蛋白反应，并对健康产生多种益处。最近，全身振动（WBV）作为一种模拟运动出现了，对于那些不能进行传统运动的人来说，这种运动可能更容易接受。Objects 作为一项正在进行的纵向双胞胎队列亲子研究的一部分，招募了 229 名成年人（32.8 ± 0.4 岁，66.7% 为女性，53.5% 为非西班牙裔黑人）。根据体重指数将参与者分为三组：肥胖者（OB：≥30 kg/m2）、超重者（OW：≥25 和 <30 kg/m2）或体重正常者（NW：<25 kg/m2）。急性 WBV 方案包括 10 个周期 1 分钟的振动运动，然后是 30 秒的站立休息。结果NW 和 OW 的反应相似，因此将这两组合并进行分析（NW/OW：BMI < 30 kg/m2）。总体而言，与前期（8.71 ± 0.19 pg/mL）相比，后期（8.80 ± 0.19 pg/mL）的循环中装饰素浓度较高（p < 0.001），而1H（8.66 ± 0.19 pg/mL）和3H（8.68 ± 0.19 pg/mL）的循环中装饰素浓度明显较低（p's ≤ 0.005）。与NW/OW组（8.77 ± 0.20 pg/mL）相比，OB组（8.82 ± 0.18 pg/mL）的Decorin POST更高（p = 0.016）。总体而言，与前期（53.49 ± 1.04 pg/mL）相比，后期（54.93 ± 1.04 pg/mL）肌生长激素较高（p = 0.002），24 小时（49.13 ± 1.04 pg/mL）较低（p < 0.001）。与男性和非西班牙裔黑人相比，女性和非西班牙裔白人的肌节蛋白反应分别较低（p's ≤ 0.001）。此外，在评估肌动蛋白对 WBV 的反应时，还应考虑脂肪含量、性别和种族。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.