Establishment of Reference Intervals for Common Renal and Liver Function Parameters in Healthy Adults in Mogadishu, Somalia: A Cross-Sectional Study

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2024-09-16 DOI:10.2147/ijgm.s480478

Abdifatah Abdullahi Jalei, Abdifetah Ibrahim Omar, Shafie Abdulkadir Hassan, Yahye Sheikh Abdulle Hassan, Nur Rashid Ahmed

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Abstract

Introduction: Reference intervals (RIs) are crucial for the accurate interpretating of laboratory test results in clinical settings, serving as benchmarks for evaluating individual health status. This study investigates the influence of sex and age on common liver function tests (LFTs) and renal function tests (RFTs) in healthy adults in Mogadishu, Somalia.
Methods: A community-based cross-sectional study was carried out from October 2022 to January 2023 on a randomly selected sample of 255 healthy participants from Mogadishu, Somalia. Approximately 5 mL of whole blood was collected from each participant and processed screening of hepatitis B and C, and human immunodeficiency virus, and then biochemical analyses were conducted for common liver and kidney parameters.
Results: The study found significant sex and age-related differences in the measured LFTs and RFTs parameters. For LFTs, males had higher levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) compared to females (ALT: 11.5 vs 7.5 U/L; AST: 25.5 vs 19.1 U/L; both p < 0.001). Age-related differences were also observed, with individuals aged 30 and above had higher levels of ALT and AST compared to those aged 18– 29 (ALT: 10.9 vs 8.5 U/L; AST: 24.3 U/L vs 21.0 U/L, both p < 0.001). For RFTs, males had higher levels of creatinine (0.9 vs 0.7 mg/dL), urea (23.1 vs 16.1 mg/dL), and uric acid (5.2 vs 4.2 mg/dL) than females, all with p < 0.001.
Conclusion: The study established population specific RIs for common liver and renal function parameters and revealed significant variations across sex and age groups. These findings underscore the importance of developing and using local RIs to ensure accurate clinical interpretation and effective patient management. Further research with larger sample sizes and in diverse regions of Somalia is highly recommended.

Keywords: reference intervals, liver function tests, renal function tests, Mogadishu, Somalia

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索马里摩加迪沙健康成人常见肾功能和肝功能参数参考区间的确定：横断面研究

简介参考区间（RIs）是准确解释临床化验结果的关键，也是评估个人健康状况的基准。本研究调查了索马里摩加迪沙健康成年人的性别和年龄对常见肝功能检测（LFTs）和肾功能检测（RFTs）的影响：方法：2022 年 10 月至 2023 年 1 月，我们在索马里摩加迪沙随机抽取了 255 名健康参与者，开展了一项基于社区的横断面研究。每位参与者采集约 5 毫升全血，进行乙型肝炎、丙型肝炎和人类免疫缺陷病毒筛查，然后对常见的肝脏和肾脏参数进行生化分析：结果：研究发现，所测得的 LFTs 和 RFTs 参数存在明显的性别和年龄差异。在 LFTs 方面，男性的丙氨酸氨基转移酶（ALT）和天门冬氨酸氨基转移酶（AST）水平高于女性（ALT：11.5 vs 7.5 U/L；AST：25.5 vs 19.1 U/L；P 均为 0.001）。还观察到与年龄有关的差异，30 岁及以上人群的谷丙转氨酶和谷草转氨酶水平高于 18-29 岁人群（谷丙转氨酶：10.9 U/L vs 8.5 U/L；谷草转氨酶：24.3 U/L vs 21.0 U/L，均为 p <0.001）。就 RFTs 而言，男性的肌酐（0.9 vs 0.7 mg/dL）、尿素（23.1 vs 16.1 mg/dL）和尿酸（5.2 vs 4.2 mg/dL）水平高于女性，P 均为 0.001：该研究确定了常见肝肾功能参数的特定人群相关指数，并揭示了不同性别和年龄组之间的显著差异。这些发现强调了制定和使用本地相关指标的重要性，以确保准确的临床解释和有效的患者管理。强烈建议在索马里不同地区开展样本量更大的进一步研究。关键词：参考区间；肝功能检测；肾功能检测；摩加迪沙；索马里

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.