Nilam S. Dhane, Suraj R. Attar, Aboli C. Sapkal, Santosh B. Kamble, Kishor V. Gaikwad
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引用次数: 0
Abstract
In this study, we report a simple, green, effective, and enhanced method for synthesizing pyranopyrazole from four-component condensation of aldehyde, malononitrile, ethyl aceto-acetate, and hydrazine hydrate employing four components in one pot that is multicomponent reactions (MCRs). Multicomponent reactions carried out by using a universal solvent; water has a quality position in organic and green synthesis. By using an aqueous hydrotropic solution and ultra-probe sonication, raising the rate of reaction and getting an excellent yield are the main features of this article. Key features of the current practice include the use of non-hazardous reaction conditions, operational simplicity, and the use of cost-effective initiating substances. The pure product can be isolated easily through simple filtration, eliminating the need for column chromatography. The process yields excellent results and is time-efficient. Additionally, the hydrotrope can be recycled up to five times without significant loss of activity, making it highly beneficial for meeting industrial needs and addressing environmental concerns.
期刊介绍：
Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry.
The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.
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