Provincial and connector qualities of somatosensory brain network hubs in bipolar disorder.

IF 2.9 2区医学 Q2 NEUROSCIENCES

Cerebral cortex Pub Date : 2024-09-03 DOI:10.1093/cercor/bhae366

Anna Luisa Klahn,William Hedley Thompson,Imiele Momoh,Christoph Abé,Benny Liberg,Mikael Landén

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Abstract

Brain network hubs are highly connected brain regions serving as important relay stations for information integration. Recent studies have linked mental disorders to impaired hub function. Provincial hubs mainly integrate information within their own brain network, while connector hubs share information between different brain networks. This study used a novel time-varying analysis to investigate whether hubs aberrantly follow the trajectory of other brain networks than their own. The aim was to characterize brain hub functioning in clinically remitted bipolar patients. We analyzed resting-state functional magnetic resonance imaging data from 96 euthymic individuals with bipolar disorder and 61 healthy control individuals. We characterized different hub qualities within the somatomotor network. We found that the somatomotor network comprised mainly provincial hubs in healthy controls. Conversely, in bipolar disorder patients, hubs in the primary somatosensory cortex displayed weaker provincial and stronger connector hub function. Furthermore, hubs in bipolar disorder showed weaker allegiances with their own brain network and followed the trajectories of the limbic, salience, dorsal attention, and frontoparietal network. We suggest that these hub aberrancies contribute to previously shown functional connectivity alterations in bipolar disorder and may thus constitute the neural substrate to persistently impaired sensory integration despite clinical remission.

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双相情感障碍患者躯体感觉大脑网络枢纽的省区和连接器特质。

脑网络枢纽是高度连接的脑区，是信息整合的重要中继站。最新研究表明，精神障碍与中枢功能受损有关。省枢纽主要整合本脑网内的信息，而连接器枢纽则在不同脑网之间共享信息。本研究采用了一种新颖的时变分析方法，来研究中枢是否会异常地跟随其他脑网络的轨迹，而不是其自身的轨迹。目的是描述临床缓解的双相情感障碍患者的大脑中枢功能。我们分析了96名双相情感障碍患者和61名健康对照者的静息态功能磁共振成像数据。我们描述了躯体运动网络中不同枢纽的特征。我们发现，健康对照组的躯体运动网络主要由省级枢纽组成。相反，在双相情感障碍患者中，初级躯体感觉皮层中的枢纽显示出较弱的省级枢纽功能和较强的连接器枢纽功能。此外，双相情感障碍患者的中枢与自身大脑网络的忠诚度较弱，并遵循边缘、显著性、背侧注意和前顶叶网络的轨迹。我们认为，这些中枢失常导致了之前所显示的双相情感障碍的功能连接改变，因此可能构成了尽管临床症状有所缓解，但感觉统合功能仍持续受损的神经基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.