Effectiveness of water system chemical disinfection against Pseudomonas aeruginosa infections, despite a not-so-obvious connection

IF 3.8 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2024-09-16 DOI:10.1016/j.ajic.2024.08.028

Adrien Turban PharmD , Amélie Morin-Le Bihan PharmD , Lucille Derbier , Caroline Piau-Couapel PharmD , Nicolas Nesseler MD, PhD , Vincent Cattoir PharmD, PhD , Pierre-Yves Donnio PharmD, PhD , Guillaume Ménard PharmD, PhD

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引用次数: 0

Abstract

Background

Pseudomonas aeruginosa is a well-recognized opportunistic pathogen frequently responsible for hospital-acquired infections. Acquisition routes of P aeruginosa are both endogenous and exogenous, including transmission from a portion of the hospital water system.

Methods

The impact of disinfection procedures of the water system and description routes of P aeruginosa transmission in a surgical intensive care unit over a 2-year period were investigated. Two distinct periods A and B were considered, respectively, before and after the disinfection. Fourier transform infrared spectroscopy was used to compare isolates recovered from patients and tap water.

Results

Overall, 21.3% of tap water samples were positive but with a significantly lower rate in period B. Concomitantly, the prevalence of patients positive for P aeruginosa decreased from 2.6% to 1%, suggesting a correlation between the presence of environmental sources and patient contaminations. The results revealed that 18% of patients were involved in cross-transmission events not related to any isolate recovered from water, suggesting transmission through care practices. Conversely, only 1 environmental transmission event was suspected in a patient.

Conclusions

Although the link between the hospital environment and patients was unclear, HCW-associated care practices could be related to contaminated point-of-use waters and then indirect spreading to patients.

查看原文本刊更多论文

供水系统化学消毒对铜绿假单胞菌感染的有效性，尽管两者之间的联系并不明显。

背景铜绿假单胞菌是一种公认的机会性病原体，经常导致医院感染。铜绿假单胞菌的感染途径有内源性和外源性两种，其中包括从医院供水系统的一部分传播。分别考虑了消毒前和消毒后的两个不同时期 A 和 B。结果总体而言，21.3%的自来水样本呈阳性，但 B 阶段的阳性率明显较低（P< 0.01）。与此同时，铜绿假单胞菌阳性的患者比例从 2.6% 降至 1%（p< 0.01），这表明环境来源和患者污染之间存在相关性。结果显示，18%的患者涉及交叉传播事件，与从水中分离出的任何菌株无关，这表明是通过护理操作传播的。结论虽然医院环境与患者之间的联系尚不明确，但与人机工程相关的护理操作可能与受污染的使用点水有关，然后间接传播给患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)