Comment on: “Herpes Zoster in neuro-ophthalmology: a practical approach”

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Duncan Marston, Sara Xuereb
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Abstract

We have read with great interest the recent article by Tao et al. [1] which provides the reader with a concise overview regarding the neuro-ophthalmic manifestations of herpes zoster and their management. However, we would like to make a comment regarding what in our opinion is a clinical misinterpretation of Hutchinson’s sign as a predictor of neuro-ophthalmic disease.

In 1866, Sir Jonathan Hutchinson documented “My cases [n = 13] are as yet too few in number to authorize a confident statement, but thus far I have never seen the whole side of the nose affected without also witnessing inflammation of the eye and I have never seen the eye inflame unless the side of the nose showed vesicles.” [2]. A prospective study carried out by Adam et al. [3] did not find any statistical significance between Hutchinson’s sign (nasociliary nerve involvement) and herpes zoster ophthalmicus (p = 0.184). However, statistical significance was approached when Hutchinson’s sign coexisted with blepharitis and conjunctivitis (p = 0.067). Furthermore, supratrocheal nerve involvement showed greater statistical significance (pvalue = 0.0004) for the development of herpes zoster ophthalmicus, whilst having a positive predictive value of 0.6 and a negative predictive value of 0.89 for associated eye involvement [3].

评论"神经眼科中的带状疱疹:实用方法
我们饶有兴趣地阅读了 Tao 等人最近发表的文章[1],这篇文章为读者提供了有关带状疱疹神经眼科表现及其治疗的简明概述。1866 年,乔纳森-哈钦森爵士(Sir Jonathan Hutchinson)记录道:"我的病例[n = 13]还太少,无法做出肯定的陈述,但迄今为止,我从未见过整个鼻侧受累而眼部未发炎的病例,也从未见过眼部发炎而鼻侧未出现水泡的病例"[2]。[2].Adam 等人进行的一项前瞻性研究[3]并未发现 Hutchinson 征(鼻睫神经受累)与带状疱疹性眼炎之间有任何统计学意义(P = 0.184)。然而,当 Hutchinson 征与睑缘炎和结膜炎并存时,则接近统计学意义(p = 0.067)。此外,眶上神经受累对带状疱疹眼炎的发生具有更大的统计学意义(p 值 = 0.0004),而对相关眼部受累的阳性预测值为 0.6,阴性预测值为 0.89 [3]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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