Associations of static and dynamic iris parameters in healthy Chinese individuals: the Handan Eye Study

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-18 DOI:10.1038/s41433-024-03345-1

Jin Wang, Tingting Liu, Sizhen Li, Mingguang He, Xiaofei Wang, Ningli Wang, Ye Zhang

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Abstract

Purpose

To determine the associations between the demographic factors (age and sex) and physiological dynamic iris changes and explore the associated factors for iris cross-sectional area (IA) change in healthy Chinese individuals.

Methods

This cross-sectional study included individuals aged ≥40 years with an open angle and underwent anterior segment optical coherence tomography under light and dark conditions from the follow-up cohort of the Handan Eye Study. Ocular data from the right eye were analyzed. The Pearson correlation coefficient was used to assess the relationship between age and iris parameters, including iris thickness (IT), IA, and iris curvature (IC), as well as the pupil diameter (PD) in the dark, and their changes from light to dark conditions. Linear regression analysis was performed to identify the potential factors associated with IA change.

Results

The final analysis included 465 healthy individuals. PD in dark, IA change and PD change decreased with age (P < 0.001), whereas IC increased with age (P < 0.001). IT and IT change were smaller, and IC was larger in women than that in men (P = 0.021, 0.007, and 0.010, respectively). Older age (P = 0.041), larger lens thickness (P = 0.013), larger IC change (P < 0.001), and smaller PD change (P < 0.001) were significantly associated with a smaller IA change.

Conclusions

Our study demonstrated the associations of static and dynamic iris parameters in healthy Chinese individuals. The findings provided a possible explanation for the higher prevalence of primary angle closure disease in elderly and female populations.

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中国健康人虹膜静态和动态参数的关联：邯郸眼科研究

目的确定人口统计学因素（年龄和性别）与虹膜生理学动态变化之间的关系，并探讨中国健康人虹膜横截面积（IA）变化的相关因素。方法该横断面研究纳入了邯郸眼科研究随访队列中年龄≥40岁、有开眼角且在明暗条件下接受了前节光学相干断层扫描的个体。对右眼的眼部数据进行了分析。采用皮尔逊相关系数评估年龄与虹膜参数之间的关系，包括虹膜厚度（IT）、IA、虹膜曲率（IC）以及黑暗条件下的瞳孔直径（PD），以及它们在明暗条件下的变化。进行了线性回归分析，以确定与 IA 变化相关的潜在因素。黑暗中的内径、内径变化和内径变化随着年龄的增长而减小（P < 0.001），而内径随着年龄的增长而增大（P < 0.001）。与男性相比，女性的 IT 和 IT 变化较小，IC 较大（P = 0.021、0.007 和 0.010）。年龄较大（P = 0.041）、晶状体厚度较大（P = 0.013）、IC 变化较大（P < 0.001）和 PD 变化较小（P < 0.001）与 IA 变化较小显著相关。我们的研究证明了中国健康人的静态和动态虹膜参数之间的关联，这些发现为原发性闭角疾病在老年人和女性人群中的高发病率提供了可能的解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464