Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study

IF 2.7 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Clinical Hypertension Pub Date : 2024-09-14 DOI:10.1111/jch.14890

Hong Ding, Jingtao Wang, Shu Liu, Yafei Xie, Xiaowei Zhang, Jing Yu

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Abstract

The fibrosis‐4 index (FIB‐4) is a noninvasive fibrosis test that is recommended for patients who are at risk of developing hepatic fibrosis. The aim of the study was to explore the correlation between FIB‐4 index and the decline of cognitive function among older patients with hypertension. The study used a cross‐sectional design to analyze data obtained from the NHANES 2011–2014. The significance of the FIB‐4 index correlation with cognitive function in individuals over the age of 60 was evaluated via multivariate regression models. The nonlinear link was described and fitted smoothed curves. There were a total of 2039 participants in the study, and those with a higher FIB‐4 index were more susceptible to developing cognitive decline. In the completely adjusted model, the association remained statistically significant between the FIB‐4 index and poor cognitive function as measured by CERAD: Total Score (OR = 0.72, 0.57−0.91), Animal Fluency Score (OR = 0.66, 0.48−0.91), and Digit Symbol Score (OR = 0.36, 0.17−0.77). A nonlinear association was found between the FIB‐4 and poor cognitive ability: Total Score, CERAD: Score Delayed Recall, Digit Symbol Score, and Animal Fluency Score. In elderly patients with hypertension, a high FIB‐4 index is correlated with an increased prevalence of cognitive decline. Hence, the FIB‐4 index could potentially serve as a valuable tool for determining individuals with hypertension who are susceptible to both liver‐related complications and cognitive impairment.

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老年高血压患者的纤维化-4 指数与认知障碍之间的关系：横断面研究

肝纤维化-4指数（FIB-4）是一种无创肝纤维化检测方法，推荐用于有肝纤维化风险的患者。本研究旨在探讨 FIB-4 指数与老年高血压患者认知功能下降之间的相关性。研究采用横断面设计，分析了从 2011-2014 年国家健康调查（NHANES）中获得的数据。通过多变量回归模型评估了 FIB-4 指数与 60 岁以上人群认知功能相关性的意义。对非线性联系进行了描述，并拟合了平滑曲线。该研究共有 2039 名参与者，FIB-4 指数越高的人越容易出现认知功能衰退。在完全调整模型中，FIB-4指数与CERAD测量的认知功能低下之间的关系仍具有统计学意义：总分（OR = 0.72，0.57-0.91）、动物流畅度得分（OR = 0.66，0.48-0.91）和数字符号得分（OR = 0.36，0.17-0.77）。FIB-4 与认知能力差之间存在非线性关联：总分、CERAD：得分延迟回忆、数字符号得分和动物流畅性得分。在老年高血压患者中，FIB-4 指数高与认知能力下降的发生率增加相关。因此，FIB-4指数有可能成为一种有价值的工具，用于确定哪些高血压患者容易出现肝脏相关并发症和认知障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Hypertension PERIPHERAL VASCULAR DISEASE-

CiteScore

5.80

自引率

7.10%

发文量

191

审稿时长

4-8 weeks

期刊介绍： The Journal of Clinical Hypertension is a peer-reviewed, monthly publication that serves internists, cardiologists, nephrologists, endocrinologists, hypertension specialists, primary care practitioners, pharmacists and all professionals interested in hypertension by providing objective, up-to-date information and practical recommendations on the full range of clinical aspects of hypertension. Commentaries and columns by experts in the field provide further insights into our original research articles as well as on major articles published elsewhere. Major guidelines for the management of hypertension are also an important feature of the Journal. Through its partnership with the World Hypertension League, JCH will include a new focus on hypertension and public health, including major policy issues, that features research and reviews related to disease characteristics and management at the population level.