Executive Functions are Independently Associated with Cognitive Dispersion in HIV Disease.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-17 DOI:10.1093/arclin/acae073

Romeo Penheiro,Troy A Webber,Andrew M Kiselica,Steven Paul Woods

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Abstract

OBJECTIVE People with HIV (PWH) can demonstrate elevated cognitive intraindividual variability (IIV-dispersion) that is associated with everyday functioning problems. Higher IIV-dispersion is theorized to reflect lapses in executive aspects of cognitive control, but few studies have directly evaluated this possibility. METHOD 72 PWH completed the Cogstate and clinical measures of executive functions, psychomotor speed, and episodic memory. IIV-dispersion was calculated with the coefficient of variation (CoV) from six age-adjusted Cogstate subtest scores. RESULTS Multiple regression showed that the three domain-level cognitive predictors explained 8% of the variance in Cogstate CoV (p = .03). Within this model, poorer executive functions were moderately associated with higher Cogstate CoV (p = .01), but the psychomotor and episodic memory domains were not (ps > .05). CONCLUSIONS Findings align with cognitive theory in demonstrating IIV-dispersion is uniquely associated with independent measures of executive functions among PWH. Future experimental and mechanistic studies are needed to determine the precise executive aspects of IIV-dispersion.

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执行功能与艾滋病患者的认知离散性密切相关。

目的艾滋病病毒感染者（PWH）会表现出较高的认知个体内变异性（IIV-分散性），这与日常功能问题有关。72 名艾滋病病毒感染者完成了 Cogstate 和执行功能、精神运动速度和外显记忆的临床测量。多重回归结果显示，三个领域级认知预测因子解释了 Cogstate CoV 8%的方差（p = .03）。在该模型中，较差的执行功能与较高的 Cogstate CoV 有中度相关性（p = .01），但精神运动和表象记忆领域没有相关性（ps > .05）。未来需要进行实验和机理研究，以确定 IIV 分散的确切执行方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464