Deciphering the response to BCMA CAR T cell therapy

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-09-19 DOI:10.1038/s43018-024-00826-w

Hamza Hassan, Marco L. Davila

引用次数: 0

Abstract

Despite the promise of chimeric antigen receptor (CAR) T cell therapy, predicting patient response is challenging. Single-cell multiomics of myeloma treated with B cell maturation antigen (BCMA)-targeted CAR T cells now reveal that poor clinical response is associated with an immunosuppressive environment and CAR T cells transition to exhausted phenotypes, indicating a mechanism for reduced persistence.

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解密BCMA CAR T细胞疗法的反应

尽管嵌合抗原受体（CAR）T细胞疗法前景广阔，但预测患者的反应却很困难。以B细胞成熟抗原（BCMA）为靶点的CAR T细胞治疗骨髓瘤的单细胞多组学研究现在揭示出，不良临床反应与免疫抑制环境和CAR T细胞过渡到衰竭表型有关，这表明了持续性降低的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.