Therapeutic potential of Cordyceps sinensis targeting oxidative stress and inflammatory response in the treatment of COPD rats: insights from metabolomics analysis.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-09-17 DOI:10.1080/10286020.2024.2403611

Ying-Ying Liu,Gai-Jie Dou,Yuan-Can Xiao,Xiao-Yi Chen,Li-Xin Wei,Wen-Bin Zhou

引用次数: 0

Abstract

This study aimed to investigate the effects of wild Cordyceps sinensis on chronic obstructive pulmonary disease (COPD) rats through metabolomics approach, combined with biochemical parameters evaluations. Consequently, C. sinensis exhibited regulatory effects on the lung's metabolic profiles in COPD rats. Treatment with C. sinensis potentially modulated glycerophospholipid metabolism, glutathione metabolism, and tryptophan metabolism, thereby alleviating oxidative stress (by decreasing MDA and GSSG, while increasing SOD and GSH) and inflammatory response (by inhibiting TNF-α, IL-8, and MMP-9) in COPD rats while improving lung tissue damage.

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冬虫夏草针对氧化应激和炎症反应治疗慢性阻塞性肺病大鼠的治疗潜力：代谢组学分析的启示。

本研究旨在通过代谢组学方法，结合生化参数评估，研究野生冬虫夏草对慢性阻塞性肺病（COPD）大鼠的影响。结果表明，野生冬虫夏草对慢性阻塞性肺病大鼠肺部代谢轮廓有调节作用。使用冬虫夏草可调节甘油磷脂代谢、谷胱甘肽代谢和色氨酸代谢，从而减轻 COPD 大鼠的氧化应激（通过降低 MDA 和 GSSG，同时增加 SOD 和 GSH）和炎症反应（通过抑制 TNF-α、IL-8 和 MMP-9），同时改善肺组织损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.