Cellular and Molecular Effects of Steroid Sex Hormones on the Vocal Folds: A Scoping Review

IF 2.2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laryngoscope Pub Date : 2024-09-13 DOI:10.1002/lary.31771

Serena Pu BA, Spencer Johnson BA, Lily Martin MLIS, Benjamin Laitman MD, PhD, Mark Courey MD

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引用次数: 0

Abstract

Objective

Steroid sex hormones (SSH) target cell nuclei to affect transcription. Although laryngeal tissue is theorized to be hormonally responsive, SSH receptor presence and cellular effects on the vocal folds are not well-established. A scoping review of this literature might inform future research.

Data Sources

Medline, Embase, Scopus, and Web of Science were searched.

Review Methods

This review followed JBI and PRISMA-ScR Guidelines. Two independent reviewers screened each title/abstract and full text according to eligibility criteria. Exclusion criteria included primary outcomes based on subjective interpretation and secondary effects on the vocal folds (e.g., voice).

Results

Three hundred and sixty one articles were screened at the title/abstract level, 83 at the full-text level, and 32 met inclusion criteria. Fourteen studies were performed in humans and 15 in animals; 3 were review articles. In studies directly examining receptors (n = 17), estrogen receptors (ER) were found in 10 of 15 studies, progesterone receptors (PR) in 6/10, and androgen receptors (AR) in 6/9. When the effects of SSH on vocal folds were studied (n = 16), estrogen had effects in 10/13, progesterone in 3/3, and androgens in 4/5. ER and PR were mostly identified in epithelium and fibroblasts of lamina propria (LP) while AR was found in muscle, lamina propria, and epithelium.

Conclusions

Existing evidence variably supports the presence of SSH receptors in vocal fold tissue; therefore, further clarification is needed. Estrogen and progesterone were most identified in mucosal tissue, where they decrease fibrosis and help maintain the epithelial barrier. Androgens appear to be pro-fibrotic in epithelium and hypertrophic in muscle. Laryngoscope, 135:540–554, 2025

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类固醇性激素对声带褶皱的细胞和分子影响：范围界定综述

目的类固醇性激素（SSH）以细胞核为目标影响转录。虽然理论上喉部组织对激素有反应，但 SSH 受体的存在以及对声带的细胞效应尚未得到充分证实。数据来源检索了Medline、Embase、Scopus和Web of Science。综述方法本综述遵循JBI和PRISMA-ScR指南。两位独立审稿人根据资格标准筛选了每篇标题/摘要和全文。排除标准包括基于主观解释的主要结果和对声带的次要影响（如嗓音）。结果在标题/摘要层面筛选了 361 篇文章，在全文层面筛选了 83 篇文章，其中 32 篇符合纳入标准。其中 14 项研究以人类为对象，15 项研究以动物为对象；3 项研究为综述性文章。在直接检测受体的研究中（n = 17），15 项研究中有 10 项发现了雌激素受体 (ER)，6/10 项发现了孕酮受体 (PR)，6/9 项发现了雄激素受体 (AR)。当研究 SSH 对声带的影响时（n = 16），雌激素在 10/13 项研究中产生了影响，孕酮在 3/3 项研究中产生了影响，雄激素在 4/5 项研究中产生了影响。ER和PR主要存在于上皮细胞和固有膜（LP）的成纤维细胞中，而AR则存在于肌肉、固有膜和上皮细胞中。雌激素和孕酮在粘膜组织中的发现最多，它们能减少纤维化并有助于维持上皮屏障。雄激素似乎会促进上皮细胞纤维化和肌肉肥大。喉镜，2024 年

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来源期刊

Laryngoscope 医学-耳鼻喉科学

CiteScore

6.50

自引率

7.70%

发文量

500

审稿时长

2-4 weeks

期刊介绍： The Laryngoscope has been the leading source of information on advances in the diagnosis and treatment of head and neck disorders since 1890. The Laryngoscope is the first choice among otolaryngologists for publication of their important findings and techniques. Each monthly issue of The Laryngoscope features peer-reviewed medical, clinical, and research contributions in general otolaryngology, allergy/rhinology, otology/neurotology, laryngology/bronchoesophagology, head and neck surgery, sleep medicine, pediatric otolaryngology, facial plastics and reconstructive surgery, oncology, and communicative disorders. Contributions include papers and posters presented at the Annual and Section Meetings of the Triological Society, as well as independent papers, "How I Do It", "Triological Best Practice" articles, and contemporary reviews. Theses authored by the Triological Society’s new Fellows as well as papers presented at meetings of the American Laryngological Association are published in The Laryngoscope. • Broncho-esophagology • Communicative disorders • Head and neck surgery • Plastic and reconstructive facial surgery • Oncology • Speech and hearing defects