89Zr PET imaging guided validation of the medicinal potentiality of UiO-66 based nano drug delivery system

IF 1.5 3区 化学 Q3 CHEMISTRY, ANALYTICAL
Fuyuan Tan, Wenliang Li, Long Qiu, Jie Lyu, Haiyue Peng, Wenbing Ding, Jiali Liao, Yuanyou Yang, Ning Liu, Feize Li
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引用次数: 0

Abstract

In this work, positron nuclide 89Zr was introduced to verify the medical feasibility of UiO-66 as a medical nanodrug carrier via positron emission tomography-computed tomography (PET–CT) imaging. A radiopharmaceutical nanodrug, DOX@89Zr-UiO-66-PEG-FA, was well constructed through subsequent doxorubicin (DOX) encapsulation and surface PEGylation of UiO-66 nanocarrier radiolabeled with 89Zr. Subsequently, tumoricidal effect of DOX@89Zr-UiO-66-PEG-FA in murine breast cancer (4T1) models had been evaluated. DOX@89Zr-UiO-66-PEG-FA has acceptable stability, excellent cargo loading rate (79.28%), pH-stimulated response property and high cancer cell binding affinity. As a result, PET–CT guided anticancer investigations reveal that DOX@89Zr-UiO-66-PEG-FA can well suppress tumor growth with satisfactory biosafety.

Graphic abstract

Abstract Image

89Zr PET 成像引导验证基于 UiO-66 的纳米给药系统的药用潜力
本研究引入了正电子核素89Zr,通过正电子发射断层扫描(PET-CT)成像验证了UiO-66作为医用纳米药物载体的医学可行性。通过对89Zr放射性标记的UiO-66纳米载体进行多柔比星(Doxorubicin,DOX)包裹和表面PEG化处理,成功构建了放射性药物纳米载体DOX@89Zr-UiO-66-PEG-FA。随后,在小鼠乳腺癌(4T1)模型中评估了 DOX@89Zr-UiO-66-PEG-FA 的杀瘤效果。DOX@89Zr-UiO-66-PEG-FA具有可接受的稳定性、优异的载药率(79.28%)、pH刺激响应特性和较高的癌细胞结合亲和力。因此,PET-CT引导的抗癌研究表明,DOX@89Zr-UiO-66-PEG-FA能很好地抑制肿瘤生长,生物安全性令人满意。
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来源期刊
CiteScore
2.80
自引率
18.80%
发文量
504
审稿时长
2.2 months
期刊介绍: An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
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