Fuyuan Tan, Wenliang Li, Long Qiu, Jie Lyu, Haiyue Peng, Wenbing Ding, Jiali Liao, Yuanyou Yang, Ning Liu, Feize Li
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引用次数: 0
Abstract
In this work, positron nuclide 89Zr was introduced to verify the medical feasibility of UiO-66 as a medical nanodrug carrier via positron emission tomography-computed tomography (PET–CT) imaging. A radiopharmaceutical nanodrug, DOX@89Zr-UiO-66-PEG-FA, was well constructed through subsequent doxorubicin (DOX) encapsulation and surface PEGylation of UiO-66 nanocarrier radiolabeled with 89Zr. Subsequently, tumoricidal effect of DOX@89Zr-UiO-66-PEG-FA in murine breast cancer (4T1) models had been evaluated. DOX@89Zr-UiO-66-PEG-FA has acceptable stability, excellent cargo loading rate (79.28%), pH-stimulated response property and high cancer cell binding affinity. As a result, PET–CT guided anticancer investigations reveal that DOX@89Zr-UiO-66-PEG-FA can well suppress tumor growth with satisfactory biosafety.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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