Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature

IF 9.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Obesity Reports Pub Date : 2024-09-17 DOI:10.1007/s13679-024-00588-7

Pei Wen Tung, Vidhu V. Thaker, Dympna Gallagher, Allison Kupsco

{"title":"Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature","authors":"Pei Wen Tung, Vidhu V. Thaker, Dympna Gallagher, Allison Kupsco","doi":"10.1007/s13679-024-00588-7","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>This narrative review summarizes current literature on the relationship of mitochondrial biomarkers with obesity-related characteristics, including body mass index and body composition.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>Mitochondria, as cellular powerhouses, play a pivotal role in energy production and the regulation of metabolic process. Altered mitochondrial functions contribute to obesity, yet evidence of the intricate relationship between mitochondrial dynamics and obesity-related outcomes in human population studies is scarce and warrants further attention.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>We discuss emerging evidence linking obesity and related health outcomes to impaired oxidative phosphorylation pathways, oxidative stress and mtDNA variants, copy number and methylation, all hallmark of suboptimal mitochondrial function. We also explore the influence of dietary interventions and metabolic and bariatric surgery procedures on restoring mitochondrial attributes of individuals with obesity. Finally, we report on the potential knowledge gaps in the mitochondrial dynamics for human health for future study.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"116 1","pages":""},"PeriodicalIF":9.5000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Obesity Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13679-024-00588-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of Review

This narrative review summarizes current literature on the relationship of mitochondrial biomarkers with obesity-related characteristics, including body mass index and body composition.

Recent Findings

Mitochondria, as cellular powerhouses, play a pivotal role in energy production and the regulation of metabolic process. Altered mitochondrial functions contribute to obesity, yet evidence of the intricate relationship between mitochondrial dynamics and obesity-related outcomes in human population studies is scarce and warrants further attention.

Summary

We discuss emerging evidence linking obesity and related health outcomes to impaired oxidative phosphorylation pathways, oxidative stress and mtDNA variants, copy number and methylation, all hallmark of suboptimal mitochondrial function. We also explore the influence of dietary interventions and metabolic and bariatric surgery procedures on restoring mitochondrial attributes of individuals with obesity. Finally, we report on the potential knowledge gaps in the mitochondrial dynamics for human health for future study.

Abstract Image

查看原文本刊更多论文

人类群体研究中的线粒体健康标志物和肥胖相关健康：最新文献综述

综述目的这篇叙述性综述总结了线粒体生物标志物与肥胖相关特征（包括体重指数和身体成分）之间关系的现有文献。线粒体功能的改变是导致肥胖的原因之一，但在人类人群研究中，线粒体动力学与肥胖相关结果之间错综复杂关系的证据还很少，值得进一步关注。摘要我们讨论了将肥胖和相关健康结果与氧化磷酸化途径受损、氧化应激和 mtDNA 变异、拷贝数和甲基化联系起来的新证据，这些都是线粒体功能不达标的标志。我们还探讨了饮食干预、代谢和减肥手术对恢复肥胖症患者线粒体属性的影响。最后，我们报告了线粒体动力学对人类健康的潜在知识缺口，供今后研究参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Obesity Reports Medicine-General Medicine

CiteScore

16.40

自引率

1.10%

发文量

期刊介绍： The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.