The Association Between Triglyceride Glucose-Body Mass Index and Kidney Impairment in Patients with Type 2 Diabetes Mellitus

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-16 DOI:10.2147/dmso.s477836

Nan Huang, Bing Lu, Zhuan-Zhuan Zhu, Xiang-Yun Zhu, Sheng Chen, Zhi-Yi Shu, Gai-Fang Liu, You-Fan Peng, Ling Li

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Abstract

Purpose: Insulin resistance is associated with kidney impairment in patients with type 2 diabetes mellitus (T2DM). The triglyceride glucose-body mass index (TyG-BMI), which combines the TyG index with body mass index (BMI), has received significant attention as a tool for evaluating insulin resistance. Thus, the aim of this study was to explore the association between TyG-BMI and kidney impairment in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods: The cross-sectional analysis included 1080 patients with T2DM, and data were collected retrospectively. TyG-BMI was calculated by fasting blood glucose, triglyceride, and body mass index.
Results: TyG-BMI was significantly higher in T2DM patients with albuminuria than those without albuminuria (232.16 [206.52– 268.02] vs 229.83 [206.11– 255.64], p =0.023). T2DM patients with chronic kidney disease (CKD) showed a significantly higher value of TyG-BMI compared with those without CKD (232.23 [206.46– 268.28] vs 229.73 [206.11– 255.49], p=0.014). Correlation analysis showed a significantly positive association between TyG-BMI and metabolic parameters including BMI (r = 0.866, p < 0.001), TG (r = 0.630, p < 0.001), TC (r = 0.119, p < 0.001), HDL-C (r = − 0.374, p < 0.001), FBG (r = 0.297, p < 0.001), and HbA1c (r = 0.116, p < 0.001) in patients with T2DM. The binary logistic regression analysis found that TyG-BMI was an independent factor for albuminuria (OR = 1.004, 95% CI: 1.001– 1.008, p = 0.010) and CKD (OR = 1.005, 95% CI: 1.001– 1.008, p = 0.005) in patients with T2DM respectively.
Conclusion: The study suggests that TyG-BMI is associated with kidney impairment in patients with T2DM. Given that TyG-BMI is a novel parameter of insulin resistance, the study results indicates that clinicians should pay close attention to screening for kidney impairment in T2DM patients with insulin resistance.

Keywords: type 2 diabetes mellitus, TyG-BMI, insulin resistance, kidney impairment

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2 型糖尿病患者甘油三酯-葡萄糖-体重指数与肾功能损害之间的关系

目的：胰岛素抵抗与 2 型糖尿病（T2DM）患者的肾功能损害有关。甘油三酯血糖体重指数（TyG-BMI）将 TyG 指数与体重指数（BMI）相结合，作为一种评估胰岛素抵抗的工具受到了广泛关注。因此，本研究旨在探讨 TyG-BMI 与 2 型糖尿病（T2DM）患者肾功能损害之间的关系：横断面分析包括 1080 名 T2DM 患者，数据以回顾性方式收集。通过空腹血糖、甘油三酯和体重指数计算TyG-BMI：有白蛋白尿的 T2DM 患者的 TyG-BMI 明显高于无白蛋白尿的患者（232.16 [206.52- 268.02] vs 229.83 [206.11- 255.64]，P =0.023）。患有慢性肾脏疾病（CKD）的 T2DM 患者的 TyG-BMI 值明显高于无 CKD 患者（232.23 [206.46- 268.28] vs 229.73 [206.11- 255.49]，P=0.014）。相关分析表明，TyG-BMI 与代谢参数之间存在明显的正相关，包括 BMI（r = 0.866，p < 0.001）、TG（r = 0.630，p < 0.001）、TC（r = 0.119，p <；0.001）、HDL-C（r = - 0.374，p <；0.001）、FBG（r = 0.297，p <；0.001）和 HbA1c（r = 0.116，p <；0.001）。二元逻辑回归分析发现，TyG-BMI分别是T2DM患者白蛋白尿（OR = 1.004，95% CI: 1.001- 1.008，p = 0.010）和CKD（OR = 1.005，95% CI: 1.001- 1.008，p = 0.005）的独立因素：研究表明，TyG-BMI 与 T2DM 患者的肾功能损害有关。鉴于 TyG-BMI 是胰岛素抵抗的一个新参数，研究结果表明临床医生应密切关注有胰岛素抵抗的 T2DM 患者的肾功能损害筛查。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464