The Association Between Triglyceride Glucose-Body Mass Index and Kidney Impairment in Patients with Type 2 Diabetes Mellitus

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-09-16 DOI:10.2147/dmso.s477836

Nan Huang, Bing Lu, Zhuan-Zhuan Zhu, Xiang-Yun Zhu, Sheng Chen, Zhi-Yi Shu, Gai-Fang Liu, You-Fan Peng, Ling Li

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Abstract

Purpose: Insulin resistance is associated with kidney impairment in patients with type 2 diabetes mellitus (T2DM). The triglyceride glucose-body mass index (TyG-BMI), which combines the TyG index with body mass index (BMI), has received significant attention as a tool for evaluating insulin resistance. Thus, the aim of this study was to explore the association between TyG-BMI and kidney impairment in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods: The cross-sectional analysis included 1080 patients with T2DM, and data were collected retrospectively. TyG-BMI was calculated by fasting blood glucose, triglyceride, and body mass index.
Results: TyG-BMI was significantly higher in T2DM patients with albuminuria than those without albuminuria (232.16 [206.52– 268.02] vs 229.83 [206.11– 255.64], p =0.023). T2DM patients with chronic kidney disease (CKD) showed a significantly higher value of TyG-BMI compared with those without CKD (232.23 [206.46– 268.28] vs 229.73 [206.11– 255.49], p=0.014). Correlation analysis showed a significantly positive association between TyG-BMI and metabolic parameters including BMI (r = 0.866, p < 0.001), TG (r = 0.630, p < 0.001), TC (r = 0.119, p < 0.001), HDL-C (r = − 0.374, p < 0.001), FBG (r = 0.297, p < 0.001), and HbA1c (r = 0.116, p < 0.001) in patients with T2DM. The binary logistic regression analysis found that TyG-BMI was an independent factor for albuminuria (OR = 1.004, 95% CI: 1.001– 1.008, p = 0.010) and CKD (OR = 1.005, 95% CI: 1.001– 1.008, p = 0.005) in patients with T2DM respectively.
Conclusion: The study suggests that TyG-BMI is associated with kidney impairment in patients with T2DM. Given that TyG-BMI is a novel parameter of insulin resistance, the study results indicates that clinicians should pay close attention to screening for kidney impairment in T2DM patients with insulin resistance.

Keywords: type 2 diabetes mellitus, TyG-BMI, insulin resistance, kidney impairment

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2 型糖尿病患者甘油三酯-葡萄糖-体重指数与肾功能损害之间的关系

目的：胰岛素抵抗与 2 型糖尿病（T2DM）患者的肾功能损害有关。甘油三酯血糖体重指数（TyG-BMI）将 TyG 指数与体重指数（BMI）相结合，作为一种评估胰岛素抵抗的工具受到了广泛关注。因此，本研究旨在探讨 TyG-BMI 与 2 型糖尿病（T2DM）患者肾功能损害之间的关系：横断面分析包括 1080 名 T2DM 患者，数据以回顾性方式收集。通过空腹血糖、甘油三酯和体重指数计算TyG-BMI：有白蛋白尿的 T2DM 患者的 TyG-BMI 明显高于无白蛋白尿的患者（232.16 [206.52- 268.02] vs 229.83 [206.11- 255.64]，P =0.023）。患有慢性肾脏疾病（CKD）的 T2DM 患者的 TyG-BMI 值明显高于无 CKD 患者（232.23 [206.46- 268.28] vs 229.73 [206.11- 255.49]，P=0.014）。相关分析表明，TyG-BMI 与代谢参数之间存在明显的正相关，包括 BMI（r = 0.866，p < 0.001）、TG（r = 0.630，p < 0.001）、TC（r = 0.119，p <；0.001）、HDL-C（r = - 0.374，p <；0.001）、FBG（r = 0.297，p <；0.001）和 HbA1c（r = 0.116，p <；0.001）。二元逻辑回归分析发现，TyG-BMI分别是T2DM患者白蛋白尿（OR = 1.004，95% CI: 1.001- 1.008，p = 0.010）和CKD（OR = 1.005，95% CI: 1.001- 1.008，p = 0.005）的独立因素：研究表明，TyG-BMI 与 T2DM 患者的肾功能损害有关。鉴于 TyG-BMI 是胰岛素抵抗的一个新参数，研究结果表明临床医生应密切关注有胰岛素抵抗的 T2DM 患者的肾功能损害筛查。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.