METS-IR, a Novel Simple Insulin Resistance Index, is Associated with NAFLD in Patients with Type 2 Diabetes Mellitus

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-09-17 DOI:10.2147/dmso.s476398

Xuan Ma, Baolan Ji, Wenhua Du, Shuwei Shi, Hongyan Zhao, Jie Sheng, Xinghe Jiang, Bo Ban, Guanqi Gao

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引用次数: 0

Abstract

Purpose: Substantial evidence has established a strong association between non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM) and insulin resistance (IR). Insulin resistance metabolic score (METS-IR) is a new and more effective comprehensive indicator for measuring IR. Our aim was to investigate the relationship between METS-IR and NAFLD in T2DM population.
Patients and methods: This cross-sectional study included 1097 adult patients with T2DM. Anthropometric measurements and biochemical indicators were collected, and the NAFLD was diagnosed by ultrasound. The METS-IR was calculated. Based on the presence of NAFLD, the population was divided into non-NAFLD and NAFLD groups. The relationship between METS-IR and NAFLD was evaluated.
Results: Compared with the non-NAFLD group, the METS-IR was higher in the NAFLD group (P < 0.001). The incidence rate of NAFLD increased across the quartiles of the METS-IR (P < 0.001). Spearman correlation analysis showed that METS-IR was positively correlated with NAFLD (Correlation Coefficient: 0.441, P < 0.001). The binary logistic regression analysis indicated that METS-IR was independently associated with NAFLD (OR: 1.120, 95% CI 1.080– 1.161). Furthermore, the area under the receiver operating characteristic curve of the METS-IR was 0.781 (95% CI 0.746– 0.817) and relatively higher than other evaluation variables.
Conclusion: In patients with T2DM, METS-IR is closely associated with NAFLD, and might be a valuable predictor of NAFLD. Further research is needed to verify this association.

Keywords: Type 2 diabetes mellitus, NAFLD, insulin resistance, METS-IR

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新型简易胰岛素抵抗指数 METS-IR 与 2 型糖尿病患者的非酒精性脂肪肝有关

目的：大量证据表明，非酒精性脂肪肝（NAFLD）、2 型糖尿病（T2DM）和胰岛素抵抗（IR）之间存在密切联系。胰岛素抵抗代谢评分（METS-IR）是衡量胰岛素抵抗的一个新的、更有效的综合指标。我们的目的是研究T2DM人群中METS-IR与非酒精性脂肪肝之间的关系：这项横断面研究包括 1097 名 T2DM 成年患者。收集了人体测量数据和生化指标，并通过超声波诊断了非酒精性脂肪肝。计算出 METS-IR 值。根据是否存在非酒精性脂肪肝，人群被分为非非酒精性脂肪肝组和非酒精性脂肪肝组。评估METS-IR与非酒精性脂肪肝之间的关系：与非 NAFLD 组相比，NAFLD 组的 METS-IR 较高（P < 0.001）。非酒精性脂肪肝的发病率随 METS-IR 的四分位数增加而增加（P < 0.001）。斯皮尔曼相关分析表明，METS-IR 与非酒精性脂肪肝呈正相关（相关系数：0.441，P <0.001）。二元逻辑回归分析表明，METS-IR 与非酒精性脂肪肝独立相关（OR：1.120，95% CI 1.080-1.161）。此外，METS-IR的接收者操作特征曲线下面积为0.781（95% CI 0.746-0.817），相对高于其他评估变量：结论：在T2DM患者中，METS-IR与非酒精性脂肪肝密切相关，可能是预测非酒精性脂肪肝的重要指标。需要进一步研究来验证这种关联：2型糖尿病非酒精性脂肪肝胰岛素抵抗 METS-IR

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.