A Reduced Resistance, Concentric-Gated Artificial Membrane Lung for Pediatric End-Stage Lung Failure.

IF 3.1 3区医学 Q2 ENGINEERING, BIOMEDICAL

ASAIO Journal Pub Date : 2024-09-16 DOI:10.1097/mat.0000000000002308

Lauren A Wich,Leah M Gudex,Tyler M Dann,Hannah J Matich,Alex J Thompson,Michael Atie,Matthew D Johnson,Robert H Bartlett,Alvaro Rojas-Peña,Ronald B Hirschl,Joseph A Potkay

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Abstract

The goal of the low-resistance pediatric artificial lung (PAL-LR) is to serve as a pumpless bridge-to-transplant device for children with end-stage lung failure. The PAL-LR doubles the exposed fiber length of the previous PAL design. In vitro and in vivo studies tested hemocompatibility, device flow, gas exchange and pressure drop performance. For in vitro tests, average rated blood flow (outlet SO2 of 95%) was 2.56 ± 0.93 L/min with a pressure drop of 25.88 ± 0.90 mm Hg. At the targeted pediatric flow rate of 1 L/min, the pressure drop was 8.6 mm Hg compared with 25 mm Hg of the PAL. At rated flow, the average O2 and CO2 transfer rates were 101.75 ± 10.81 and 77.93 ± 8.40 mL/min, respectively. The average maximum O2 and CO2 exchange efficiencies were 215.75 ± 22.93 and 176.99 ± 8.40 mL/(min m2), respectively. In vivo tests revealed an average outlet SO2 of 100%, and average pressure drop of 2 ± 0 mm Hg for a blood flow of 1.07 ± 0.02 L/min. Having a lower resistance, the PAL-LR is a promising step closer to a pumpless artificial membrane lung that alleviates right ventricular strain associated with idiopathic pulmonary hypertension.

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用于小儿终末期肺衰竭的减阻同心门控人工膜肺

低阻力儿科人工肺（PAL-LR）的目标是为终末期肺衰竭的儿童提供一种无泵桥移植装置。PAL-LR 的外露纤维长度是之前 PAL 设计的两倍。体外和体内研究测试了血液相容性、设备流量、气体交换和压降性能。在体外测试中，平均额定血流量（出口 SO2 为 95%）为 2.56 ± 0.93 L/min，压降为 25.88 ± 0.90 mm Hg。在 1 升/分钟的目标儿科流速下，压降为 8.6 毫米汞柱，而 PAL 为 25 毫米汞柱。在额定流量下，氧气和二氧化碳的平均转移率分别为 101.75 ± 10.81 mL/min 和 77.93 ± 8.40 mL/min。平均最大氧气和二氧化碳交换效率分别为 215.75 ± 22.93 和 176.99 ± 8.40 mL/（min m2）。体内测试显示，在 1.07 ± 0.02 升/分钟的血流量下，平均出口 SO2 为 100%，平均压降为 2 ± 0 mm Hg。PAL-LR 的阻力较低，有望向无泵人工膜肺迈进一步，减轻与特发性肺动脉高压相关的右心室负荷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ASAIO Journal 医学-工程：生物医学

CiteScore

6.60

自引率

7.10%

发文量

651

审稿时长

4-8 weeks

期刊介绍： ASAIO Journal is in the forefront of artificial organ research and development. On the cutting edge of innovative technology, it features peer-reviewed articles of the highest quality that describe research, development, the most recent advances in the design of artificial organ devices and findings from initial testing. Bimonthly, the ASAIO Journal features state-of-the-art investigations, laboratory and clinical trials, and discussions and opinions from experts around the world. The official publication of the American Society for Artificial Internal Organs.