Mutual Influence Between Allergic Rhinitis and Sleep: Factors, Mechanisms, and interventions—A Narrative Review

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-09-19 DOI:10.2147/nss.s482258

Ting Yang, Han-Rui Wang, Ya-Kui Mou, Wan-Chen Liu, Yao Wang, Xiao-Yu Song, Chao Ren, Xi-Cheng Song

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引用次数: 0

Abstract

Abstract: Patients with allergic rhinitis (AR) have a high incidence of sleep disorders, such as insomnia, which can easily exacerbate nasal symptoms. The aggravation of nasal symptoms further promotes the deterioration of sleep disorders, forming a vicious cycle. Severe cases may even trigger psychological and neurological issues, such as anxiety, depression, and cognitive impairment, causing significant distress to patients, making clinical diagnosis and treatment difficult, and increasing costs. Furthermore, satisfactory therapeutics remain lacking. As the pathogenesis of AR-associated sleep disorders is not clear and research is still insufficient, paying attention to and understanding AR-related sleep disorders is crucial in clinical practice. Multiple studies have shown that the most crucial issues in current research on AR and sleep are analyzing the relationship between AR and sleep disorders, searching for the influencing factors, and investigating potential targets for diagnosis and treatment. This review aimed to identify and summarize the results of relevant studies using “AR” and “sleep disorders” as search terms. In addition, we evaluated the correlation between AR and sleep disorders and examined their interaction and potential mechanisms, offering a foundation for additional screening of potential diagnostic biomarkers and therapeutic targets.

Keywords: allergic rhinitis, biological rhythm, immune inflammatory, neurological regulation, sleep disorders

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过敏性鼻炎与睡眠之间的相互影响：因素、机制和干预措施--叙述性综述

摘要：过敏性鼻炎（AR）患者失眠等睡眠障碍的发病率很高，而失眠很容易加重鼻部症状。鼻部症状的加重会进一步促进睡眠障碍的恶化，形成恶性循环。严重者甚至会引发焦虑、抑郁和认知障碍等心理和神经问题，给患者造成极大困扰，给临床诊断和治疗带来困难，并增加费用。此外，目前仍缺乏令人满意的治疗方法。由于AR相关睡眠障碍的发病机制尚不明确，研究仍显不足，因此关注和了解AR相关睡眠障碍在临床实践中至关重要。多项研究表明，目前 AR 与睡眠研究中最关键的问题是分析 AR 与睡眠障碍之间的关系、寻找影响因素以及研究潜在的诊断和治疗靶点。本综述旨在以 "AR "和 "睡眠障碍 "为检索词，识别并总结相关研究的结果。此外，我们还评估了AR与睡眠障碍之间的相关性，研究了它们之间的相互作用和潜在机制，为进一步筛选潜在的诊断生物标志物和治疗靶点奠定了基础。关键词：过敏性鼻炎；生物节律；免疫炎症；神经调节；睡眠障碍

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.