Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis

IF 1.7 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Qinghua Yin, Na Guo, Ping Fu, Hui Zhong
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Abstract

Objective The aim of this study was to investigate iron status and iron deficiency in incident continuous ambulatory peritoneal dialysis (CAPD) patients and identify influencing factors. Methods Patients with end-stage renal disease were enrolled. Clinical data of iron metabolism and biochemical and dialysis parameters during the first peritoneal dialysis evaluation were collected. Serum ferritin (SF) and transferrin saturation (TSAT) levels were evaluated, and independent influencing factors were identified by correlation and regression analyses. Results Of 1,128 adult CAPD patients, 41.2% had iron deficiency (ID), 15.7% had absolute iron deficiency, and 8.2% had functional iron deficiency. The average SF level was (276.8 ± 277.9) μg/L, and iron saturation was (29.8 ± 12.7)%. Additionally, 50.2 and 69.3% of patients reached targets in SF level and iron saturation recommended by the Chinese Society of Nephrology. SF level and TSAT were not correlated with estimated glomerular filtration rate, whereas negatively correlated with platelet count and inflammatory factors. Low platelet count, presence of diabetes mellitus and high interleukin 6 levels were independent factors of lower TSAT. Conclusions ID is common in patients with CAPD. Women and those with thrombocytopenia, diabetes, and inflammation are at higher risk for iron storage or reduced iron utilization. In the initial CAPD stage, a reasonable iron supplement strategy may be established for CAPD patients with high-risk factors.
评估接受连续不卧床腹膜透析患者的铁代谢和缺铁情况
目的 本研究旨在调查连续不卧床腹膜透析(CAPD)患者的铁状况和铁缺乏症,并确定影响因素。方法 登记终末期肾病患者。收集首次腹膜透析评估期间铁代谢的临床数据以及生化和透析参数。评估了血清铁蛋白(SF)和转铁蛋白饱和度(TSAT)水平,并通过相关和回归分析确定了独立的影响因素。结果 在 1128 名成年 CAPD 患者中,41.2% 患有缺铁症(ID),15.7% 患有绝对缺铁症,8.2% 患有功能性缺铁症。平均 SF 水平为 (276.8 ± 277.9) μg/L,铁饱和度为 (29.8 ± 12.7)%。此外,分别有 50.2% 和 69.3% 的患者达到了中华医学会肾脏病学分会推荐的 SF 水平和铁饱和度目标。SF 水平和 TSAT 与估计肾小球滤过率无关,而与血小板计数和炎症因子呈负相关。低血小板计数、糖尿病和高白细胞介素 6 水平是 TSAT 降低的独立因素。结论 ID 常见于 CAPD 患者。女性和患有血小板减少症、糖尿病和炎症的患者铁储存或铁利用率降低的风险更高。在 CAPD 初期,可为具有高危因素的 CAPD 患者制定合理的铁补充策略。
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来源期刊
Open Medicine
Open Medicine Medicine-General Medicine
CiteScore
3.00
自引率
0.00%
发文量
153
审稿时长
20 weeks
期刊介绍: Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.
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