{"title":"Early life epigenetics and childhood outcomes: a scoping review","authors":"Srirupa Hari Gopal, Theresa Alenghat, Mohan Pammi","doi":"10.1038/s41390-024-03585-7","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Epigenetics is the study of changes in gene expression, without a change in the DNA sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation, histone modifications, and small non-coding RNA (sncRNA) changes have been studied in various childhood disorders. Causal links to maternal health and toxin exposures can introduce epigenetic modifications to the fetal DNA, which can be detected in the cord blood. Cord blood epigenetic modifications provide evidence of in-utero stressors and immediate postnatal changes, which can impact both short and long-term outcomes in children. The mechanisms of these epigenetic changes can be leveraged for prevention, early detection, and intervention, and to discover novel therapeutic modalities in childhood diseases. We report a scoping review of early life epigenetics, the influence of maternal health, maternal toxin, and drug exposures on the fetus, and its impact on perinatal, neonatal, and childhood outcomes.</p><h3 data-test=\"abstract-sub-heading\">Impact statement:</h3><ul>\n<li>\n<p>Epigenetic changes such as DNA methylation, histone modification, and non-coding RNA have been implicated in the pathophysiology of various disease processes.</p>\n</li>\n<li>\n<p>The fundamental changes to an offspring’s epigenome can begin in utero, impacting the immediate postnatal period, childhood, adolescence, and adulthood.</p>\n</li>\n<li>\n<p>This scoping review summarizes current literature on the impact of early life epigenetics, especially DNA methylation on childhood health outcomes</p>\n</li>\n</ul>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41390-024-03585-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Epigenetics is the study of changes in gene expression, without a change in the DNA sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation, histone modifications, and small non-coding RNA (sncRNA) changes have been studied in various childhood disorders. Causal links to maternal health and toxin exposures can introduce epigenetic modifications to the fetal DNA, which can be detected in the cord blood. Cord blood epigenetic modifications provide evidence of in-utero stressors and immediate postnatal changes, which can impact both short and long-term outcomes in children. The mechanisms of these epigenetic changes can be leveraged for prevention, early detection, and intervention, and to discover novel therapeutic modalities in childhood diseases. We report a scoping review of early life epigenetics, the influence of maternal health, maternal toxin, and drug exposures on the fetus, and its impact on perinatal, neonatal, and childhood outcomes.
Impact statement:
Epigenetic changes such as DNA methylation, histone modification, and non-coding RNA have been implicated in the pathophysiology of various disease processes.
The fundamental changes to an offspring’s epigenome can begin in utero, impacting the immediate postnatal period, childhood, adolescence, and adulthood.
This scoping review summarizes current literature on the impact of early life epigenetics, especially DNA methylation on childhood health outcomes
摘要表观遗传学是一门研究基因表达变化的学科，这种变化不会改变 DNA 序列，但有可能遗传。表观遗传学机制，如DNA甲基化、组蛋白修饰和小非编码RNA（sncRNA）变化，已在各种儿童疾病中得到研究。与孕产妇健康和毒素接触的因果关系可导致胎儿 DNA 的表观遗传修饰，而这些修饰可在脐带血中检测到。脐带血中的表观遗传修饰提供了胎儿体内压力因素和产后即刻变化的证据，这些变化会对儿童的短期和长期结果产生影响。这些表观遗传变化的机制可用于预防、早期检测和干预，以及发现儿童疾病的新型治疗方法。影响声明：DNA 甲基化、组蛋白修饰和非编码 RNA 等表观遗传学变化与各种疾病过程的病理生理学有关。后代表观基因组的基本变化可从子宫内开始，影响产后、儿童期、青春期和成年期。本范围综述总结了目前有关生命早期表观遗传学，尤其是 DNA 甲基化对儿童健康结果影响的文献。
期刊介绍：
Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of children''s diseases and
disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in vitro techniques
relevant to developmental biology and medicine are acceptable, as are translational human studies
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
