Impact of metabolic and weight components on incident asthma using a real-world cohort

IF 5.8 2区医学 Q1 ALLERGY

Annals of Allergy Asthma & Immunology Pub Date : 2024-12-01 DOI:10.1016/j.anai.2024.09.005

Melissa H. Bloodworth MD, PhD , Patrick J. Staso MD , Shi Huang PhD , Eric Farber-Eger BS , Kevin D. Niswender MD, PhD , Frank E. Harrell Jr PhD , Quinn S. Wells MD , Leonard B. Bacharier MD , Megan M. Shuey PhD , Katherine N. Cahill MD

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引用次数: 0

Abstract

Background

Obesity and metabolic dysregulation (MetD) have increasing prevalence and adversely affect asthma morbidity and therapeutic response.

Objective

To determine the role of weight and MetD on incident asthma in adulthood.

Methods

In a retrospective, longitudinal cohort of patients, we performed a time-to-asthma diagnosis analysis after a 3-year landmark period (t₀-t₃) during which weight and MetD components were evaluated. We assessed incident asthma risk with MetD components and weight.

Results

In total, 90,081 patients met the inclusion criteria, with 836 cases (0.93%) of incident asthma in our primary cohort. Diabetes present at t₀, but no other MetD components, was associated with increased risk of asthma (adjusted hazard ratio = 1.85, 95% CI: 1.27-2.71, P = .0002). The effect of weight on asthma risk, independent of other MetD components, identified individuals with overweight or obesity as having a 10-year attributable risk of 15.4%. Metformin was prescribed more frequently, and hemoglobin A1c levels were lower in patients with diabetes in whom asthma did not develop (P < .0001).

Conclusion

Weight and diabetes prevention and management represent modifiable risk factors for adult asthma development.

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利用真实世界队列研究代谢和体重因素对哮喘发病的影响。

背景肥胖和代谢失调（MetD）的发病率越来越高，对哮喘的发病率和治疗反应产生了不利影响。方法在一个回顾性纵向患者队列中，我们在三年的标志性时期（t0-t3）后进行了哮喘诊断时间分析，在此期间对体重和 MetD 成分进行了检查。结果 90,081 名患者符合纳入标准，其中有 836 例（0.93%）在我们的主要队列中发生哮喘。t0时存在糖尿病，但没有其他MetD成分，与哮喘风险增加有关（HRadj = 1.85，95% CI：1.27 - 2.71，p=0.0002）。体重对哮喘风险的影响与其他 MetD 成分无关，超重或肥胖者的 10 年归因风险为 15.4%。未患哮喘的糖尿病患者服用二甲双胍的频率更高，血红蛋白 A1c 水平更低（P<0.0001）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Allergy Asthma & Immunology 医学-过敏

CiteScore

6.50

自引率

6.80%

发文量

437

审稿时长

33 days

期刊介绍： Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.