Beyond complete remission: A comparative analysis of long-term laryngeal function in patients with hypopharyngeal and laryngeal cancer following radiotherapy and concurrent chemoradiation

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-14 DOI:10.1002/hed.27935

Gene Huh MD, Eun-Jae Chung MD, PhD, Won Shik Kim MD, PhD, Seong Keun Kwon MD, PhD, Myung-Whun Sung MD, PhD, Bhumsuk Keam MD, PhD, Hong-Gyun Wu MD, PhD, Joo Ho Lee MD, PhD, Jin Ho Kim MD, PhD, Soon-Hyun Ahn MD, PhD

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Abstract

Background

This study evaluates functional larynx preservation in patients with hypopharyngeal cancer (HPC) and laryngeal cancer (LC) who achieved complete remission following radiotherapy (RT) or concurrent chemoradiation (CCRT).

Methods

HPC and LC patients treated with RT/CCRT from 1999 to 2017 were retrospectively analyzed. Severe late dysphagia and tracheostomy cases were assessed to determine laryngeal function. Long-term preservation rate of functional larynx and associated factors were evaluated.

Results

Of 152 patients (55 HPC, 97 LC), nine developed severe dysphagia, occurring on average 58.2 months post-treatment. HPC and cervical node metastasis significantly increased the risk of laryngeal function impairment (p < 0.001 and p = 0.014, respectively), presenting a continued decline in functional larynx preservation rate beyond 10 years.

Conclusions

Patients with HPC and cervical node metastasis demonstrate an increased risk for long-term laryngeal function impairment despite successful oncologic outcomes. This risk extends beyond 10 years, underscoring the need for prolonged monitoring and comprehensive support.

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超越完全缓解：下咽癌和喉癌患者接受放疗和同期化疗后长期喉功能的比较分析

背景本研究评估了在放疗（RT）或同期化疗（CCRT）后获得完全缓解的下咽癌（HPC）和喉癌（LC）患者的喉功能保留情况。方法回顾性分析了1999年至2017年接受RT/CCRT治疗的下咽癌和喉癌患者。对晚期严重吞咽困难和气管切开病例进行评估，以确定喉功能。结果 152 例患者（55 例 HPC，97 例 LC）中，9 例出现严重吞咽困难，平均发生时间为治疗后 58.2 个月。HPC和颈椎结节转移明显增加了喉功能受损的风险（分别为p < 0.001和p = 0.014），喉功能保留率在10年后持续下降。这种风险会持续 10 年以上，因此需要长期监测和全面支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.