Biomonitoring of hand and forearm transepidermal water loss and skin pH among nursing apprentices

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-09-12 DOI:10.1111/cod.14690

Željka Babić, Franka Šakić, Jelena Macan

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Abstract

Background

Measurements of transepidermal water loss (TEWL) and stratum corneum (SC) pH can help indicate work-related skin barrier damage, but sensitivity to confounding personal and ambient factors limits their potential as biomonitoring tools.

Objectives

To evaluate the difference between hand and forearm skin barrier conditions as a tool for early recognition of workers with occupational contact dermatitis.

Participants and Methods

The participants were nursing apprentices (N = 238, median age 19 years) from Zagreb, Croatia. They filled out a questionnaire based on the Nordic Occupational Skin Questionnaire, underwent a clinical examination of skin on the hands, and were evaluated for their TEWL and SC pH on the dorsum of the hand and volar part of the forearm.

Results

We found that the difference between hand and forearm TEWL values (ΔTEWL) greater than 7 g/m²/h, or >50%, or the difference in SC ΔpH >0.50, predicted visible skin changes found on clinical examination. However, only the association with ΔpH >0.50 retained statistical significance when controlled for sex, age, ambient temperature, and relative humidity in a multiple regression model.

Conclusions

The difference between hand and forearm SC pH values is suggested as a reliable biomonitoring tool in recognition of damaged skin barrier conditions in occupational settings.

Abstract Image

查看原文本刊更多论文

对护理学徒的手部和前臂经表皮失水及皮肤 PH 值进行生物监测

背景经表皮失水（TEWL）和角质层（SC）pH值的测量有助于显示与工作相关的皮肤屏障损伤，但对个人和环境因素的敏感性限制了其作为生物监测工具的潜力。参与者和方法参与者是来自克罗地亚萨格勒布的护理学徒（人数=238，中位年龄为 19 岁）。结果我们发现，手部和前臂的 TEWL 值（ΔTEWL）差值大于 7 g/m2/h 或 50%，或 SC ΔpH 差值大于 0.50，均可预测临床检查中发现的明显皮肤变化。结论手部和前臂 SC pH 值之间的差异可作为一种可靠的生物监测工具，用于识别职业环境中受损的皮肤屏障状况。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".