Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson’s disease

IF 8.7 1区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology, Neurosurgery, and Psychiatry Pub Date : 2024-09-17 DOI:10.1136/jnnp-2024-334297

Jan Rusz, Petr Dusek, Tereza Tykalova, Michal Novotny, Vojtech Illner, Michal Simek, Tomas Kouba, Petr Kryze, David Zogala, Evzen Ruzicka, Mário Sousa, Adriana Jorge, Tobias Nef, Paul Krack

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Abstract

Background Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson’s disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson’s disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere. Methods Acoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT). Results From a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index compared with patients with lower right DAT availability (p=0.01). Conclusion Our data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.

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基底神经节的言语功能是否偏向一侧？新帕金森病的证据

背景有关侧向基底节功能障碍对帕金森病患者言语可能产生的影响的研究很少。本研究旨在比较帕金森病（PD）非对称性黑质多巴胺能功能障碍（主要发生在右半球或左半球）的未服药帕金森病患者的言语能力。方法对阅读段落进行声学分析。使用多巴胺转运体-单光子发射CT（DAT-SPECT）确定黑质功能障碍的不对称性。结果在接受评估的135名新发型帕金森病患者中，根据DAT-SPECT结果，47名患者的右侧和36名患者的左侧DAT含量较低。与右侧DAT可用性较低的患者相比，左侧DAT可用性较低的帕金森病患者通过综合构音障碍指数得出的构音障碍严重程度更高（P=0.01）。结论我们的数据支持左侧大脑丘脑中的 DAT 在言语中的关键作用。这一发现可能为深部脑刺激后的言语管理提供重要线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurology, Neurosurgery, and Psychiatry 医学-精神病学

CiteScore

15.70

自引率

1.80%

发文量

888

审稿时长

6 months

期刊介绍： The Journal of Neurology, Neurosurgery & Psychiatry (JNNP) aspires to publish groundbreaking and cutting-edge research worldwide. Covering the entire spectrum of neurological sciences, the journal focuses on common disorders like stroke, multiple sclerosis, Parkinson’s disease, epilepsy, peripheral neuropathy, subarachnoid haemorrhage, and neuropsychiatry, while also addressing complex challenges such as ALS. With early online publication, regular podcasts, and an extensive archive collection boasting the longest half-life in clinical neuroscience journals, JNNP aims to be a trailblazer in the field.