{"title":"Highly Effective DPA-SCP Sonosensitizer for Biofilm Removal in Infected Root Canals via Sonodynamic Therapy","authors":"Ziheng Zhang, Yuhan Wan, Jiafei Qu, Dan Ding, Minghui Wang, Xin Yue, Jingrui Xin, Jing Shen","doi":"10.1039/d4qm00408f","DOIUrl":null,"url":null,"abstract":"Chemical debridement constitutes a pivotal phase in eradicating microbial entities during endodontic therapy. The antimicrobial efficacy of endodontic irrigants in clinical use is contingent upon their concentration; however, elevated concentrations engender significant risk to tissue integrity. Consequently, we advocate for an innovative and benign sonodynamic antimicrobial approach. This method employs the sonosensitizer DPA-SCP, which, under the influence of low-frequency ultrasonic waves, catalyzes the generation of copious reactive oxygen species (ROS). Empirical evaluations indicate that DPA-SCP demonstrates a robust antibacterial capacity towards E. faecalis suspensions and biofilms established on the internal surfaces of root canals. Moreover, its bactericidal impact is comparable to the use of 5.25% sodium hypochlorite. Moreover, DPA-SCP demonstrates markedly reduced cytotoxicity towards fibroblasts relative to conventional endodontic irrigants, and the thermal elevation induced by ultrasonic application remains within non-detrimental limits. This sonodynamic disinfection paradigm presents a valuable and prospective clinical application in endodontic sanitation.","PeriodicalId":86,"journal":{"name":"Materials Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Chemistry Frontiers","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1039/d4qm00408f","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Chemical debridement constitutes a pivotal phase in eradicating microbial entities during endodontic therapy. The antimicrobial efficacy of endodontic irrigants in clinical use is contingent upon their concentration; however, elevated concentrations engender significant risk to tissue integrity. Consequently, we advocate for an innovative and benign sonodynamic antimicrobial approach. This method employs the sonosensitizer DPA-SCP, which, under the influence of low-frequency ultrasonic waves, catalyzes the generation of copious reactive oxygen species (ROS). Empirical evaluations indicate that DPA-SCP demonstrates a robust antibacterial capacity towards E. faecalis suspensions and biofilms established on the internal surfaces of root canals. Moreover, its bactericidal impact is comparable to the use of 5.25% sodium hypochlorite. Moreover, DPA-SCP demonstrates markedly reduced cytotoxicity towards fibroblasts relative to conventional endodontic irrigants, and the thermal elevation induced by ultrasonic application remains within non-detrimental limits. This sonodynamic disinfection paradigm presents a valuable and prospective clinical application in endodontic sanitation.
期刊介绍:
Materials Chemistry Frontiers focuses on the synthesis and chemistry of exciting new materials, and the development of improved fabrication techniques. Characterisation and fundamental studies that are of broad appeal are also welcome.
This is the ideal home for studies of a significant nature that further the development of organic, inorganic, composite and nano-materials.